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Total Synthesis of (−)‐Perezoperezone through an Intermolecular [5+2] Homodimerization of Hydroxy p‐Quinone |
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| Authors: | Yang Long Yiming Ding Hai Wu Chunlei Qu Hong Liang Min Zhang Xiaoli Zhao Xianwen Long Shu Wang Pema‐Tenzin Puno Jun Deng |
| Abstract: | The first copper‐catalyzed intermolecular [5+2] homodimerization of hydroxy p‐quinone is presented, furnishing bicyclo[3.2.1]octadienone core structures in typically good yields and excellent diastereoselectivities. Applying this synthetic approach enables a concise nine‐step total synthesis of (?)‐perezoperezone from commercially available 3,5‐dimethoxytoluene. |
| Keywords: | 5+2-Cycloaddition Dimerisierung Naturstoffe Perezoperezon Totalsynthese |
