坎地沙坦对自发性高血压大鼠胰岛素抵抗及血清脂联素的影响

目的: 探讨血管紧张素II受体拮抗剂坎地沙坦对自发性高血压大鼠(SHR)糖代谢及血清脂联素的影响。方法: SHR大鼠分为两组:高血压组(SHR,n=30);坎地沙坦组(坎地沙坦,1 mg·kg^-1·d^-1,n=30, 灌胃法给药),另设同种系WKY大鼠为对照组,给予同等量安慰剂, 12周后分别用生化方法和放射免疫方法测定空腹血糖(FBG)和胰岛素水平(FINS),计算IR指数(HOMA-IR),用生化方法进行口服葡萄糖耐量试验(OGTT),ELISA分析法测定血清脂联素水平。结果: 空腹血糖高血压组和对照组大鼠差异无统计学意义(P>0.05);空腹胰岛素水平和HOMA-IR与高血压组大鼠相比,对照组和坎地沙坦组要明显降低 (P<0.05);OGTT结果显示,30 min 和 120 min 血糖水平与高血压组相比,对照组和坎地沙坦给药组明显降低(P<0.05)。血清脂联素的水平与高血压组相比,对照组和坎地沙坦大鼠明显较高(P<0.05)。结论: 血管紧张素II 受体拮抗剂坎地沙坦可以升高高血压血清脂联素水平,改善IR,降低30、120 min 餐后血糖水平。

Effect of candesartan on HOMA-IR and serum adiponectin of spontaneously hypertensive rats

AIM: To investigate the effect of candesartan, an angiotensin II receptor antagonist, on HOMA-IR and serum adiponectin of spontaneously hypertensive rats(SHRs).METHODS: SHRs were divided into two groups: Hypertension group (SHR, n=30), Candesartan group (Candesartan, 1 mg·kg^-1·d^-1, n=30, gavaging for 12 weeks).WKY rats were the control group(WKY, n=30). The other two groups were given a placebo. Fasting blood glucose and serum insulin were measured by biochemistry methods, insulin resistance index (HOMA-IR) was calculated,OGTT was tested by biochemistry methods. Changes of serum adiponectin were measured by ELISA.RESULTS: No difference in the fasting blood glucose of the three groups (P>0.05) was observed. Serum insulin level and HOMA-IR of SHRs were higher than those of WKY and drug groups (P<0.05). Candesartan could not reduce those of SHRs. Serum adiponectin level of SHRs was lower than that of WKY, and candesartan could obviously increase that of SHRs (P<0.05). The result of OGTT showed that blood glucose level at 30 min or 120 min in hypertension group compared with control group and candesartan group were higher.CONCLUSION: Candesartan could ameliorate the upregulaiton of serum adiponectin in SHR, improve insulin resistance and reduce blood glucose level of SHR at 30 min and 120 min.