中国1990-2019年儿童青少年哮喘疾病负担变化趋势

目的 探索1990-2019年中国儿童青少年哮喘疾病负担变化趋势,为开展防控工作提供参考.方法 基于2019年全球疾病负担研究,利用Joinpoint回归分析性别和年龄别哮喘疾病负担动态变化,与各级社会人口指数(SDI)国家平均水平比较;并分析归因哮喘疾病负担的变化.结果 标化1～19岁哮喘伤残调整寿命年(DALYs)...

Trends in the asthma burden among children and adolescents in China from 1990-2019

  Objective  To explore trends in the asthma burden among Chinese children and adolescents 1-19 years old during 1990-2019.  Methods  Based on data from the 2019 Global Burden of Disease Study, joinpoint regression was used to analyze the dynamic changes in the gender-and age-specific asthma burden, and the asthma burden in China was compared with countries that have different socio-demographic indices(SDI). In addition, trends in asthma burden attributed to different risk factors were also investigated.  Results  The asthma burden decreased slightly from 1990 to 1996 annual percent change (APC)=-1.7%], then rapidly decreased from 1996 to 2005 (APC=-5.7%). The age-standardized disability adjusted life years (DALYs) rate decreased from 158.55/100 000 to 88.59/100 000 in patients 1-19 years of age. From 2005 to 2017, the DALYs rate for asthma increased slowly, then rapidly. In 2017, the DALYs rate peaked at 176.18/100 000, then decreased to 126.79/100 000 in 2019. The burden of asthma in boys was higher than girls, and the DALYs rate for asthma in the group 5-9 years of age was higher than the remaining age groups. Furthermore, the age-standardized DALYs rate for asthma among Chinese children and adolescents was relatively low among countries with a different SDI. In addition, the DALYs rate attributed to high body mass index increased in all age groups in China. Specifically, the average APC (AAPC) was 2.9% in group 1-4 years of age and the AAPC was 4.2% in the remaining age groups. The DALYs rate attributed to occupational asthmagens in the group 15-19 years of age decreased from 1990 to 2019 and the AAPC was -2.5%.  Conclusion  The asthma burden was relatively low among Chinese children and adolescents, and there were gender and age differences. The gender-and age-specific DALYs rate for asthma had a tendency to decrease, increase, then decrease. More attention should be paid to boys and the group 5-9 years of age, and strengthen the intervention of obesity and occupational asthmagens.