替吉奥隔日方案联合低剂量顺铂治疗老年非小细胞肺癌疗效观察 |
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引用本文: | 胡俊,徐筱荣,熊剑华,何瑾.替吉奥隔日方案联合低剂量顺铂治疗老年非小细胞肺癌疗效观察[J].中国现代医生,2013,51(11):77-78. |
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作者姓名: | 胡俊 徐筱荣 熊剑华 何瑾 |
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作者单位: | 江西省新干县人民医院肿瘤科,江西新干,331300 |
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摘 要: | 目的 替吉奥胶囊施行隔日给药联合低剂量顺铂化疗,评价其对老年非小细胞肺癌(NSCLC)的疗效.方法 将55 例老年NSCLC患者分为两组,分别行替吉奥隔日给药联合低剂量顺铂治疗和常规剂量治疗,观察两组疗效和不良反应.结果 隔日低剂量组和常规剂量组RR率分别为26.7%和28%,1、2年生存率分别为53.3%、33.3%和56%、32%,差异无统计学意义;但隔日低剂量组Ⅲ~Ⅳ级血液性、消化道等毒性反应明显低于常规剂量组.结论 两方案近期疗效相同,但隔日低剂量组不良反应发生率低,不需水化,门诊随访治疗,实现低成本和良好患者依从性.
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关 键 词: | 替吉奥 隔日 NSCLC 老年 |
Observation of therapeutic efficacy of using S-1 every other day program and low dose DDP in the treatment of elderly patients with NSCLC |
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Authors: | HU Jun XU Xiaorong XIONG Jianhua HE Jin |
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Affiliation: | Department of Oncology, Xingan People's Hospital in Jiangxi Province, Xingan 331300, China |
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Abstract: | Objective The therapeutic efficacy of using S-1 every other day program plus low dose DDP and that of Conventional dose regimen to treat elderly patients with NSCLC were compared in this article. Methods All of 55 el- derly patents with NSCLC were divided into two groups, with one group being treated with the Gio every other day joint administration of low-dose cisplatin therapy and the other group with conventional-dose therapy for at least two cycles, during which the effects were observed and adverse reactions were performed pathological diagnosis. Results The next day, the RR rate of the low-dose group and the conventional-dose group were 26.7% and 28%, and the av- erage survival time for these two groups were respectively 53.3%, 33.3%, 56%, 32%. Therefore, the difference was not statistically significant; however, the next day the low-dose group was significantly lower than conventional dose group in Ⅲ~Ⅳ blood and gastrointestinal toxicity. Conclusion The efficacy of the two programs are the same. However, com- pared with the conventional--dose program, low-dose program has lower incidence of adverse effects, and does not need the hydration and outpatient follow-up treatment. It also has the advantages of low cost and good patient compliance. |
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Keywords: | S-1 Next day NSCLC Elderly patients |
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