Labeling of Polymer Nanostructures for Medical Imaging: Importance of crosslinking extent, spacer length, and charge density |
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| Authors: | Xu Jinqi Sun Guorong Rossin Raffaella Hagooly Aviv Li Zicheng Fukukawa Ken-Ichi Messmore Benjamin W Moore Dennis A Welch Michael J Hawker Craig J Wooley Karen L |
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| Affiliation: | Center of Materials Innovation and Department of Chemistry, Washington University in Saint Louis, Saint Louis, MO 63130. |
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| Abstract: | Radiolabeling studies were employed to investigate the influence of structure on the efficiency of surface functionalization for poly(acrylic acid)-coated shell crosslinked nanoparticles (SCKs) with two types of amine-terminated DOTA chelators. An intricate interplay between the chemical and physical properties of both the DOTA derivative and the SCK nanostructures was revealed, demonstrating the importance of structural control. |
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