一种新的N2S2配位体合成和99TcmO标记及其生物分布研究

为了寻找新的具有灌注显像能力的＾９９Ｔｃ＾ｍＯ的，合成了Ｎ２Ｓ２配位体－Ｎ，Ｎ’－二（２－巯基丙基）－１，２苯二胺（ＢＭＰＢＤＡ）。以ＳｎＣｌ２为还原剂，制备了放化纯大于９５％的＾９９Ｔｃ＾ｍＯ－ＢＭＰＢＤＡ。探讨了ＰＨ值对＾９９Ｔｃ＾ｍＯ－ＢＭＰＢＤＡ放化纯的影响，并对其在小鼠体内的生物分布进行了研究。结果表明，＾９９Ｔｃ＾ｍＯ－ＢＭＰＢＤＡ在心肌中具有相当的初始摄取和较好的滞留。静脉注射后２、

SYNTHESIS OF A NEW N2S2 LIGAND AND ITS LABELLING AND BIODISTRIBUTION OF 99TcmO-BMPBDA IN MICE

In order to find new 99 Tc mO complexes for perfusion imaging, a new N 2S 2 ligand of N, N' bis(2 mercaptopropyl) 1,2 benzenediamine(BMPBDA)has been synthesized and its 99 Tc mO complex has been prepared by using SnCl 2 as reductant. Effect of pH has been investigated. In the biodistribution study of 99 Tc mO BMPBDA in mice, high myocardial uptake and retention are demonstrated. After administration, 12.37 %/g of 99 Tc mO BMPBDA is extracted into heart in 2 min. The residence time of 99 Tc mO BMPBDA in heart is long, 10.76 %/g of 99 Tc m O BMPBDA retains in heart far 30 min postinjection. The activity clearance from blood is rapid and the clearance half life is less than 15 min, but the activity level in blood is high. This study may be valuable to the design of new 99 Tc mO complex for perfusion imaging.