南阳地区40001例患者红细胞血型不规则抗体检测分析

目的了解南阳地区患者红细胞血型不规则抗体的发生频率及特异性抗体的分布特点。方法选取就诊的患者40 001(男13 141,女26 860,男:女=0.489),用卡式微柱凝胶法进行红细胞血型不规则抗体筛查;对检出抗体阳性者鉴定其特异性及Ig类型。结果 40 001例患者中检出红细胞血型不规则抗体者347例(0.87%),其中男68/13 141例(0.52%)、女279/26 860例(1.04%),差异有统计学意义(P<0.05)。3960例孕妇检出红细胞血型不规则抗体73例(1.84%)。检出较多的特异性抗体依次为抗-M、抗-JK、抗-Lea、抗-P1、抗-Fyb、抗-Leb等。IgM类抗体183例、IgG类抗体74例、IgM+IgG类抗体28例,37℃反应阳性者62例(0.15%,62/40 001)。结论南阳地区患者红细胞血型不规则抗体发生频率和分布特点与其他地区不同,检出率较高,提示对于拟输血者特别是孕妇应例行红细胞血型不规则抗体检测。

Irregular antibodies of erythrocyte blood group of 40 001 cases in Nanyang region

Objective To study the incidence and distribution characteristics of irregnlar antibodies of erythrocyte blood group in patients of Nanyang region, Henan province. Methods 40 001 patients （male 13 141, female 26 860） were detected the erythrocyte irregular antibodies by microcolum gel Coomb＇s test. The positive patients were further identified their antibody specificity, lg type. Results 347 positives cases（0.87% ）, included 68 male cases （0.52%） and 279 female cases （ 1.04% ） were detected. 73 out of 3960 pregnant women （ 1.84% ） ; There were 183 cases of IgM type, 74 cases of IgG, 28 cases of IgM ＋ IgG, 62 cases of 37~C positive reaction. The incidence of the specificity type from high to low were anti-M ,an- ti-JK, anti-Lea, anti-Pl and anti-Fyb and anti-Leb. Conclusion The incidence of erythrocyte irregular antibodies and the spe- cificity type in Nanyang region were different from other regions and countries. This study supported to routine check erythro- cyte irregular antibodies for the patients who plan a blood transfusion.