副溶血性弧菌病原学和分子流行病学流行特征研究进展

副溶血性弧菌是导致我国细菌性食物中毒事件的首要原因.临床分离株和环境分离株的病原学特征有着明显的差异.临床分离株以O3:K6血清型为主,tdh和(或)trh基因携带率较高,一般在80%以上,脉冲场凝胶电泳(PFGE)基因图谱具有明显的优势图谱,并且与血清分型具有一致性.而环境分离株(包括食品)多无优势血清型和优势PFGE图谱,tdh和(或)trh基因携带率远低于临床分离株,多在6%以下.各地临床分离株的耐药性差异较大,但对氨苄西林等早期药物耐药率均较高.环境分离株较临床分离株的耐药性更为严重和复杂.

Progress in research of etiological and molecular epidemiological characteristics of Vibrio parahaemolyticus

Vibrio Parahaemolyticus is the major pathogen causing food-borne disease in China. This paper summarizes the progress in research of etiological and molecular epidemiological characteristics of V. parahaemolyticus in recent 5 years. The research indicated that there was obvious difference in the etiological characteristics between clinical isolates and environmental isolates. The clinical isolates mainly belonged to serotype O3:K6, and 80% of the clinical isolates carried tdh gene and(or) trh gene. The predominant PFGE pattern of the clinical isolate was obvious, consistent with the serotype. But the environmental isolates had no predominant serotype and PFGE pattern, their carriage rate of tdh gene or trh gene( 6%) was lower than that of clinical isolates. The drug resistance of the clinical isolates varied with area, and the resistance to ampicillin was high. While the drug resistance of environmental isolates was more serious and complex.