琪笋·德密格-4胶囊的主要药效学研究

目的: 探讨蒙药验方制剂琪笋·德密格-4胶囊(QD-4)的药理作用。方法: 采用高脂饲料诱发新西兰兔高脂血症动脉硬化模型;高营养饲料诱发SD大鼠单纯性肥胖模型,受试药分3个剂量组,分别预防性给予QD-4(兔:0.75,0.37,0.19 g·kg^-1;大鼠:3.24,1.62,0.81 g·kg^-1)与模型对照组、阳性药(兔:辛伐他汀0.5 mg·kg^-1;大鼠:亚油酸0.39 g·kg^-1)对照组和空白组,ig给药,连续8周。检测血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)含量和肥胖指标,观察分析主动脉粥样硬化斑块,以评价QD-4调脂、减肥作用。结果: QD-4显著降低单纯性肥胖模型SD大鼠血清TG(P<0.01),升高HDL-C(P<0.05),抑制实验鼠体重(P<0.01),缩小鼠体长,增加尾长(P<0.05),抑制脂肪细胞增长(P<0.01),作用强度优于亚油酸,但实验鼠摄食量无差别,对TC和LDL-C的影响不及亚油酸;能降低高脂动脉粥样硬化症模型新西兰兔血清TC、LDL-C(P<0.01~0.05),不同程度地减轻、减少实验兔主动脉粥样硬化程度,影响程度与辛伐他汀组相当,其他指标未显统计意义。实验显示量效关系明显,低剂量组作用不理想。结论: 蒙药琪笋·德密格-4胶囊具有调脂、减肥及抗动脉粥样硬化作用,符合蒙医升清降浊,消减"巴达干"理论。

Pharmacodynamic Activity of Qisun-Demige-Four Capsules of Mongolian Medicine

Objective: To explore the pharmacologic activity of Qisun-Demige-Four capsules (QD-4) by animal experiments. Method: The hyperlipidemia and atherosclerosis model of New Zealand rabbits and the obesity model of SD rats were induced by feeding with high-cholesterol diets or high-nutrition diets, the experimental animals were divided into three drug groups which were fed with QD-4(the doses of rabbits were 0.75,0.37,0.19 g·kg^-1, and the doses of rats were 3.24,1.62,0.81 g·kg^-1), model group, positive drug group (Simvastatin or Linoleic acid 0.5 mg·kg^-1 or 0.39 mg·kg^-1) and normal group. The concentrations of total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) in the serums and obesity indicators were detected, while aortic atherosclerotic plaque were observed and analyzed to evaluate the effect of QD-4. Result: Compared with the nutritional obese model rats, QD-4 significantly decreased TC(P<0.01), obviously increased HDL-C(P<0.05), reduced body weight(P<0.01), shortened body length, increased tail length of SD rats(P<0.01), and inhibited the growth of fat cells (the number of cells in unit horizon was increased, P<0.01), at the same time, the strength of role were better than linoleic acid. However, the food intake of each group of animals had no significantly difference(P<0.01), TC and HDL-C in QD-4 groups were less than those in linoleic acid group. Compared with the hyperlipidemia and atherosclerosis model of rabbits, QD-4 significantly decreased TC, LDL-C(P<0.01,P<0.05), reduce the lesions of atherosclerotic rabbit, in accordance with the effects of Simvastatin. Other indexes showed no statistical significance. The experimental results showed that there were obvious dose-effect relationship and the low-dose QD-4 group didn't show significant effect. Conclusion: Mongolian medicine QD-4 can adjust the disorder of lipid metabolism, reduce body weight and inhibit scleratheroma. Results correspond to Mongolian theory about clean and decreasing dirty, reduce 'Badagan'.