平喘敷贴膏对慢性阻塞性肺疾病患者肺功能 及生活质量的影响

目的: 通过平喘敷贴膏治疗160例慢性阻塞性肺疾病(COPD)患者的疗效观察,探讨其可能的机制以及发现平喘敷贴膏在慢性阻塞性肺病中的防治的优势,有利于进一步推广及应用。方法: 符合纳入标准的COPD患者160例,将入选COPD患者按照随机数字表分为治疗组、对照组,每组各80例。治疗组:COPD常规治疗(支气管扩张剂+祛痰剂+舒利迭50/250 1吸 bid+抗生素)+平喘敷贴膏敷贴;对照组:COPD常规治疗(支气管扩张剂+祛痰剂+舒利迭50/250 1吸 bid+抗生素),分别在治疗前、治疗后6个月对患者肺功能进行测定,主要检测指标为1秒用力呼气容积(FEV₁)预计值%、FEV₁/用力肺活量(FVC)、6分钟步行实验以及生活质量评分(应用SGRQ圣乔治呼吸问卷)进行比较,做出统计。结果: 平喘敷贴膏治疗组与治疗前比较FEV₁/预计值%有一定程度的改善,差异有统计学意义(P<0.05),而治疗组与对照组在对肺功能FEV₁/FVC的改善方面未发现优势,差异有统计学意义。6 min内步行距离治疗组改善明显优于对照组,差异有统计学意义(P<0.05);两组治疗前后SGRQ量表积分比较:治疗后两组SGRQ量表生活质量评分均较治疗前下降(P<0.05)。治疗组前后两组比较,除影响部分差异无统计学意义外,症状部分、活动部分及总分下降均有统计学意义(P<0.05),且治疗组下降幅度大于对照组(P<0.05),说明治疗组生活质量改善明显,治疗效果明显优于对照组。结论: 运用平喘敷贴膏穴位贴敷疗法可以一定程度的改善肺功能和缓解患者的临床症状,并且能够改善运动耐量,从而达到提高患者生活质量的目的。

Effect of Pingchuang Paste on Pulmonary Function and Quality of Life Inpatients with Chronic Obstructive Pulmonary Disease

Objective: To observe efficacy of Pingchuang paste in treatment of chronic obstructive pulmonary disease(COPD), and explore its possible mechanism. Method: One hundred and sixty cases of COPD patients met the inclusion criteria were divided into the treatment group and the control group, 80 cases in each group. The treatment group was treated with COPD conventional therapy (bronchodilator+expectorant+Seretide 50/250 1 suction bid+antibiotics)+and Pingchuang paste; the control group received COPD conventional therapy with no Pingchuang paste(bronchodilator+expectorant+Seretide 50/250 1 suction bid+antibiotics), respectively, before and after treatment of 6 months the pulmonary function was measured,major indexes including FEV₁ predicted, FEV₁/FVC, 6-minute walk test and quality of life scores (application SGRQ). Result: The treatment group compared with before treatment FEV₁ was improved, the difference was statistically significant (P<0.05), while in the treatment group and the control group the improvement of FEV₁/FVC was not found. 6 min walk in the treatment group improved significantly compared to the control group, the difference was statistically significant (P<0.05).After treatment, the SGRQ scale declined than before treatment in two groups (P<0.05). Some symptoms, the active part of the score was declined significantly (P<0.05). Conclusion: Pingchuang paste can improve pulmonary function and clinical symptoms, and improve exercise tolerance, so as to achieve the purpose of improving the quality of life.