| PCR-SSCP检测结核分枝杆菌耐利福平诊断的系统评价 |
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| 引用本文： | 甘培尚,拜争刚,李培杰,马彬,田金徽,杨克虎. PCR-SSCP检测结核分枝杆菌耐利福平诊断的系统评价[J]. 兰州大学学报(医学版), 2008, 34(2) |
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| 作者姓名： | 甘培尚 拜争刚 李培杰 马彬 田金徽 杨克虎 |
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| 作者单位： | [1]甘肃省疾病控制中心结核病预防控制所,甘肃兰州730000 [2]兰州大学循证医学中心,甘肃兰州730000 [3]兰州大学基础医学院,甘肃兰州730000 [4]兰州大学第二医院急诊科,甘肃兰州730030 |
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| 摘 要： | 目的 用Meta-分析的方法评价PCR-SSCP检测结核分枝杆菌耐利福平的准确性.方法 通过检索PUBMED、EMBASE、中国生物医学文献数据库、中国期刊全文数据库、中文科技期刊全文数据库等数据库和其他方式广泛收集文献.用QUADAS标准评价文献质量.用Meta-disc软件计算合并敏感度、合并特异度和SROC曲线下面积等.结果 最终纳入4篇外文文献(5个研究),Meta-分析显示PCR-SSCP用于结核分枝杆菌耐利福平的诊断均显示了较高的敏感度和特异度,有较高的诊断价值.其合并敏感度为97%,[95%CI(95%,99%)];合并特异度为84%,[95%CI(78%,89%)];合并阳性似然比为8.14,[95%CI(1.77,37.42)];合并阴性似然比为0.05,[95%CI(0.02,0.14)1;SROC曲线下面积:AUC=0.989 0,SE(AUC)=0.012 0.结论 目前PCR-SSCP法检测结核分枝杆菌耐利福平诊断有一定诊断价值,可作为诊断结核分枝杆菌耐利福平的确诊方法.
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| 关 键 词： | 结核分枝杆菌 利福平 系统评价 单链构象多态性分析技术 |
A systematic review of the diagnostic value of PCR-SSCP to rifampicin resistance in mycobacterium tuberculosis |
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| GAN Pei-shang BAI Zheng-gang LI Pei-jie MA Bin TIAN Jin-hui YANG Ke-hu. A systematic review of the diagnostic value of PCR-SSCP to rifampicin resistance in mycobacterium tuberculosis[J]. Journal of Lanzhou University (Medical Sciences), 2008, 34(2) |
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| Authors: | GAN Pei-shang BAI Zheng-gang LI Pei-jie MA Bin TIAN Jin-hui YANG Ke-hu |
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| Affiliation: | GAN Pei-shang~1 BAI Zheng-gang~(2,3) LI Pei-jie~4 MA Bin~(2,3) TIAN Jin-hui~(2,3) YANG Ke-hu~(2,3) (1.Tuberculosis Prevention , Control Office,Gansu Province Center for Disease Prevention , Control,Lanzhou 730000,China,2.Evidence-based Medicine Center,Lanzhou University,3.School of Basic Medicine,4.Department of Emergency,the Second Hospital of Lanzhou University,Lanzhou 730030,China) |
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| Abstract: | Objective To evaluate the diagnostic value of PCR-SSCP to rifampicin resistance in mycobacterium tuberculosis.Methods A fully recursive literature search was conducted in PUBMED,EMBASE,Chinese biomedical literature database,Chinese scientific journals full text database and China journal fulltext database,items of quality assessment of diagnostic accuracy studies were used to evaluate the quality of included studies.Meta-disc software was used to handle data from the included studies.The diagnostic value of... |
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| Keywords: | mycobacterium tuberculosis rifampicin systematic review PCR-SSCP |
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