| MGP(T-138C)基因多态性与儿童血铅水平关系的研究 |
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| 引用本文： | 张文众,冷曙光,戴宇飞,王雅文,牛勇,阎慧芳,吴宜群,郑玉新.MGP(T-138C)基因多态性与儿童血铅水平关系的研究[J].卫生研究,2003,32(6):514-515. |
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| 作者姓名： | 张文众 冷曙光 戴宇飞 王雅文 牛勇 阎慧芳 吴宜群 郑玉新 |
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| 作者单位： | 中国疾病预防控制中心职业卫生与中毒控制所,北京,100050 |
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| 基金项目： | 国家自然科学基金资助项目 (No .39770 6 40 ) |
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| 摘 要： | 为探讨基质γ 羧基谷氨酸蛋白 (MGP)基因多态性和血铅水平的关系 ,寻找与儿童铅中毒易感性有关的基因 ,测定了 3 55名 6～ 12岁的中国汉族儿童的血铅水平。采用多聚酶链反应 -限制性片段长度多态性法 (PCR RFLP)分析MGP基因T 13 8C位点的多态性。结果表明 ,在铅污染地区TT基因型儿童的血铅水平显著高于CC基因型儿童 (468 2 4μg L .vs .43 0 3 1μg L ,P <0 0 5)。结果显示MGP基因启动子区T 13 8C多态性影响生活在铅污染环境中儿童的血铅水平
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| 关 键 词： | MGP基因多态性 血铅水平 遗传易感性 儿童 |
| 文章编号： | 1000-8020(2003)06-0514-02 |
| 修稿时间： | 2003年2月23日 |
Study on association of polymorphism of MGP(T-138C) gene and blood lead level in children |
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| Zhang Wenzhong,Leng Shuguang,Dai Yufei,Wang Yawen,et al..Study on association of polymorphism of MGP(T-138C) gene and blood lead level in children[J].Journal of Hygiene Research,2003,32(6):514-515. |
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| Authors: | Zhang Wenzhong Leng Shuguang Dai Yufei Wang Yawen |
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| Affiliation: | Institute for Occupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China. |
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| Abstract: | In order to explore the relationship between polymorphism of matrix gamma-carboxyglutamic acid protein (MGP) gene and blood lead level in children and to screen the gene which associated with lead poisoning, three hundreds and fifty-five children aged at 6 to 12 years old living in lead pollution area were recruited in this study. The blood lead level were measured. The T-138C polymorphism of MGP gene was analyzed with the method of polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). The blood lead level in children with wild type homozygotes(TT) was higher than those with mutated homozygotes(CC) (468.24 micrograms/L. vs. 430.31 micrograms/L, P < 0.05). The results indicated that the T-138C polymorphism of MGP gene in promoter region influenced blood lead level in children lived in lead pollution area. |
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| Keywords: | MGP gene polymorphism blood lead level genetic susceptibility children |
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