恶性肿瘤的发病机制(一)——创伤修复自动反馈机制假说

目的探讨恶性肿瘤的发病机制。方法选取Wistar成年纯种大白鼠60只。随机分为实验组和对照组。采用生物、化学、物理等方法建立癌症动物模型。在3个月、6个月、9个月、12个月分别取创面组织和肿块一起送病检,并同时抽取尾静脉血送同位素室做放免检测。结果实验组部分大鼠长出了新生物,病理报告显示为相同的纤维肉瘤。GH、EGF、SS、IgG动态曲线与肿瘤形成有一定的相关性,不同时相数值比较(P<0.05),有统计学意义。结论恶性肿瘤的发生与细胞膜的损伤有直接关系,细胞膜的损伤和激素的自动反馈调节导致了肿瘤形成。

The Pathogenesis of Malignant Neoplasma ( 一 )--The Hypothesis about the Automatic Feedback of Repair in Trauma

Objective To explore the pathogensis of malignant neoplasma.Methods 60 Wistar adult rats were selected and randomly divided into the experimental groups and the control group.Animal models with cancer were made by many methods of biological,chemical,physcial and so on.The tissue of wound surface and lump were cut and sent for pathological examination as well as the venous blood of tail for radioimmunoassay examination after three,six,nine,twelve months.Results The pathologic examination reported that the neoplasm were the same fibrosarcoma.The curves of SS,GH,IgG and EGF is relate to the growth of tumour.There is a great difference among the comparision of data in different phases (P<0.05).Conclusion The growth of malignant tumour is directly related to the injury of cellular membrane.The injury of cellular membrane and the automatic feedback regulation of hormone result in the growth of tumour.