A yeast's eye view of mammalian reproduction: cross-species gene co-expression in meiotic prophase |
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| Authors: | Yunfei Li Ka-sum Lam Nairanjana Dasgupta Ping Ye |
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| Affiliation: | (1) School of Molecular Biosciences, Washington State University, PO Box 647520, 99164 Pullman, WA, USA;(2) Center for Reproductive Biology, Washington State University, 99164 Pullman, WA, USA;(3) Department of Statistics, Washington State University, 99164 Pullman, WA, USA |
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| Abstract: | Background Meiotic prophase is a critical stage in sexual reproduction. Aberrant chromosome recombination during this stage is a leading
cause of human miscarriages and birth defects. However, due to the experimental intractability of mammalian gonads, only a
very limited number of meiotic genes have been characterized. Here we aim to identify novel meiotic genes important in human
reproduction through computational mining of cross-species and cross-sex time-series expression data from budding yeast, mouse
postnatal testis, mouse embryonic ovary, and human fetal ovary. |
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