内皮生长因子61基因多态性与肝细胞性肝癌易感性的Meta分析

目的探讨内皮生长因子(EGF）基因多态性与肝细胞性肝癌(HCC)发病风险的关系。 方法计算机系统检索PubMed、EMABSE和中国知网等数据库，收集关于EGF 61A/G基因多态性与HCC易感性的病例对照研究，并从纳入文献中提取相关数据进行Meta分析。以病例组和对照组EGF 61A/G基因型分布的比值比(OR）为效应指标，对纳入文献进行异质性检验，应用Stata 10.1软件对各研究原始数据进行合并分析，计算合并OR值及其95%可信区间(CI）。结果共有6篇文献符合纳入标准，累计病例1 304例，对照2 613例。 G/G基因型与G/A+A/A基因型比较的OR值为1.34 (95% CI1.16~1.54，P<0.001；I2 =36%)。而A/A基因型与G/G+G/A基因型比较的OR值为0.66 (95% CI 0.53~0.83，P<0.001；I2 =0%)。结论EGF 61G/G基因型为罹患HCC的易感基因型，而EGF 61A/A基因型则为HCC的保护基因型。

A Meta-analysis on Relationship between Epidermal Growth Factor 61A/G Polymorphism and Risk of Hepatocellular Carcinoma

Objective To explore the relationship between polymorphism of epidermal growth factor(EGF) 61A/G and the risk of hepatocellular carcinoma(HCC).Methods Electronic searches of PubMed,EMBASE and CNKI were systematically conducted to select studies.Case-control studies containing available genotype frequencies of EGF 61A/G were chose.Odds ratio(OR) with 95% confidence interval(CI) was used to assess the strength of this association.Results Six case-control studies including 1 304 cases and 2 613 controls were performed.Meta-analysis showed significant effect of EGF 61A/G on HCC risk and protection(G/G vs.G/A+A/A:OR=1.34,95%CI=1.16~1.54;A/A vs.G/G+G/A:OR=0.66,95% CI=0.53~0.83).Conclusion The EGF 61G allele is a risk factor of HCC;however,the EGF 61A allele is a protective factor of HCC.