丹参酮治疗早期心肾综合征患者对N端前体脑钠肽和胱抑素C的影响

目的观察丹参酮治疗早期心肾综合征的疗效及其对N端前体脑钠肽（NT-proBNP）和胱抑素C（Cys C）水平的影响。方法选择2008年1月～2012年11月在上海市第一人民医院宝山分院就诊的早期心肾综合征患者60例,将其随机分为观察组和对照组,每组各30例。对照组予以综合治理,观察组在对照组的基础上予以丹参酮。观察两组的疗效及其治疗前后的肾小球滤过率（GRF）、尿白蛋白分泌率（UAER）、NT-proBNP和Cys C水平的变化。结果两组治疗后,观察组的总有效率为80.00%,而对照组的总有效率为53.33%,观察组的疗效优于对照组,差异有统计学意义（P〈0.05）。两组治疗7、14 d后,两组的GRF、UAER、NT-proBNP和Cys C水平较治疗前明显降低（P〈0.01）,观察组的降低水平较对照组更为明显,差异有统计学意义（P〈0.05或P〈0.01）。结论丹参酮治疗早期心肾综合征患者的疗效显著,其机制可能与降低NT-proBNP和Cys C水平有关。

Impact of the N-terminal pro-brainnatriuretie peptide and cystatin C on patients with early cardiorenal syndrome treated with Tanshinone

Objective To observe the efficacy of early cardiorenal syndrome treated with Tanshinone and their levels of the N-terminal pro-brainnatriuretie peptide （NT-proBNP）, cystatin C （Cys C）. Methods 60 patients with early cardiorenal syndrome treated in Baoshan Branch of Shanghai First People＇s Hospital from January 2008 to November 2012 were selected and randomly divided into observation group and control group, there were 30 cases in each group. The control group received comprehensive treatment, observation group was treated with Tanshinone on the basis of the control group. The efficacy was observed, and the levels of glomerular filtration rate （GRF）, urinary albumin excretion rate （UAER）, NT-proBNP and Cys C were detected before and after treatment. Results After treatment, the total effective rate was 80.00% in observation group, while 53.33% in control group, the efficacy of the observation group was better than the control group, the difference was statistically significant （P 〈 0.05）. The levels of GRF, UAER, NT- proBNP and Cys C were significantly reduced after 7 d or 14 d treatment in two groups than those before treatment （P 〈 0.01）, and the levels of the observation group reduced more obviously than those in the control group, the differences were statistically significant （P 〈 0.05 or P 〈 0.01）. Conclusion The efficacy of early cardiorenal syndrome treated with Tanshinone is obvious, and its mechanism may be associated with the decrease of NT-proBNP and Cys C.