| 4-三氟甲基苯乙酸的合成新方法 |
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| 引用本文： | 方永勤,徐冬梅. 4-三氟甲基苯乙酸的合成新方法[J]. 化学试剂, 2010, 32(4) |
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| 作者姓名： | 方永勤 徐冬梅 |
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| 作者单位： | 1. 江苏工业学院,精细化工研究所,江苏,常州,213164
2. 江苏工业学院,化学化工学院,江苏,常州,213164 |
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| 摘 要： | 以4-三氟甲基苯胺为原料,经重氮化、Grignard反应、Wolff-Kishner-黄鸣龙还原反应制得标题化合物.研究表明:n(Mg)∶n(4-三氟甲基溴苯)∶n(草酸二乙酯)=1.2∶1∶1.5、反应温度为50～60 ℃、n(4-三氟甲基苯乙酮酸乙酯)∶n(水合肼)=1∶1.2,总收率68.4%,并通过~1HNMR对中间体及产物进行了结构确证.
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| 关 键 词： | 4-三氟甲基苯乙酸 Grignard反应 Wolff-Kishner-黄鸣龙反应 |
A new method for synthesis of (4-trifluoromethylphenyl)acetic acid |
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| FANG Yong-qin,XU Dong-mei. A new method for synthesis of (4-trifluoromethylphenyl)acetic acid[J]. Chemical Reagents, 2010, 32(4) |
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| Authors: | FANG Yong-qin XU Dong-mei |
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| Abstract: | (4-Trifluoromethylphenyl)acetic acid was prepared from 4-trifluoromethylaniline through the diazotization reaction,the Grignard reaction and the Wolff-Kishner-Huang reaction.The results indicated that at a molar ratio of n(Mg)∶n(p-bromobenzotrifluoride)∶n(diethyl oxalate)=1.2∶1∶1.5,a reaction temperature of 50～60 ℃,and a molar ratio of n(ethyl 4-trifluoromethylbenzoylformate)∶n(hydrazine hydrate)=1∶1.2,the isolated product yield was 68.4%.The structure of the product and the intermediate were characterized by ~1HNMR spectroscopy. |
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| Keywords: | (4-trifluoromethylphenyl)acetic acid Grignard reaction Wolff-Kishner-Huang reaction |
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