956对夫妇外周血染色体核型与不良孕产史的关系

目的探讨不良孕产史与染色体核型异常的关系。方法取患者的外周血进行无菌培养、制片及G显带技术进行染色体核型分析。结果通过对956对夫妇染色体核型分析,发现异常核型209例,异常率为11.77%。其中臂间倒位13例,占6.22%;平衡易位28例,占13.40%;性染色体异常2例,占0.96%;染色体多态性163例,占异常总数的77.99%;其他异常3例,占1.43%。结论染色体异常以及多态性是导致不良孕产史的重要因素,因此,染色体核型分析应作为优生优育的常规检查,从而提高人口素质,降低先天性出生缺陷。

Relationshipe of chromosomal karyotype and bad history with abnormal pregnancy in 956 examples.

Objective： Apply chromosomal analysis in peripheral blood of patients with histories of abnormal pregnancy, who visited our hospital from Dec. 2011-Dec.2012, in order to explore the relationship of theabnormal karyotype and obstetric abnormality. Methods： Cultivate lymphocyte in peripheral blood in nutritive medium, analyze the karyotype using G band. Result： The 209 cases were abnormal of 958 examples, and the abnormal percentage was 11.77%. The result shows the percentage of pericentricinversionp, translocation, sex chromosome abnormalities, olymorphismand some other abnormalities were 6.22%, 13.40%, 0.96%, 77.99% and 1.43%, respectively. Conclusion： Chromosome abnormality has strong correlations with bad obstetric history, so the chromosome analysis should be treated as the routine examination of prepotency. The chromosome analysis is an effectivemeans toimprove thepopulation qualities and reduce birth defects.