原发不孕患者行短时受精、half-ICSI与常规长时受精结果的比较

目的探讨女性原发不孕患者行短时受精、half—ICSI与常规长时受精三种受精方式对受精率和胚胎发育潜能的影响。方法回顾性分析705个非男性因素导致原发不孕在本中心接受体外受精治疗，将其分为ABC三组，A组128个短时受精联合早期补救ICSI周期（A1组：112个短时IVF受精周期，A2组：16个早期补救ICSI周期），B组65个hal-ICSI周期，C组512个常规长时受精周期。对三组患者的一般情况、不同病因、促排卵方案及卵巢功能、受精、胚胎质量和妊娠情况进行分析。对A1、A2两组患者的受精、胚胎质量和妊娠情况进行分析。结果B组较A、C组不孕年限长，获卵数多，正常受精率低，且差异有统计学意义（P〈0．05）。B、c两组的3PN率明显低于短时受精组（P〈0．05），而1PN率比较无显著性差异（P〉0．05）。结论短时受精联合早期补救ICSI对原发不孕患者是一种较为合理而安全的受精方式。

Comparative analysis on the outcome of short time insemination,half - icsi and the long time insemination for female primary infertility.

Objective： To determine the effects of short time insemination, half - ICSI and long time insemination on the fertility rate and embryonic development potentiality among female primary infertility. Methods： In a retrospective study, the assisted gestation information of 705 cycles among female primary infertility patients were categorized as follows ： group A （ short time insemination and immediate rescue ICSI, n = 128） including group A1 （short time insemination, n = 112） and group A2 （immediate rescue ICSI, n = 16）. group B （half- ICSI, n =65）. group C （long time insemination, n =512）. The general state, ovary responsivity index dur- ing the process of ovulation induction, fertility rate, embryo quality, and pregnancy rate were recorded and compared among three groups. The fertility rate, embryo quality, and pregnancy rate were recorded and compared between group A1 and group A2. Results： In group B, compared with group A and group C, the infertility time was longer, the number of oocytes was higher and the fertility rate was obviously lower, with the statistical significance （P 〈 0.05）. The ratio of unnormal fertility rate in the group B and group C were lower than group A, the different were statistically significant （P 〉 0. 05）. Conclusion： The method, which short time insemination and immediate rescue ICSI are combined, is more feasible and safe for female primarv infertility.