血清VEGF、sFlt-1、NO在妊娠期高血压疾病患者中的表达水平及意义

目的探讨VEGF,sFlt-1,NO三种因子在妊娠期高血压疾病患者血清中的表达。方法选取在潍坊市妇幼保健住院分娩的80例孕妇为研究对象。实验组40例（包括妊娠期高血压组10例、轻度子痫前期组15例,重度子痫前期组15例）,正常妊娠妇女40例为对照组。比较两组患者血清中VEGF、sFlt-1及NO的表达水平。结果 1.妊娠期高血压疾病患者血清中VEGF的表达水平明显低于对照组（P〈0.05）;sFlt-1的表达水平明显高于对照组（P〈0.05）;NO的表达水平明显低于对照组（P〈0.05）,差异均有统计学意义。2.子痫前期组三种因子的变化最明显。3.实验组sFlt-1/VEGF比值与疾病严重程度呈明显正相关（P〈0.05）。实验组NO表达水平与疾病严重程度呈明显负相关（P〈0.05）。结论妊娠期高血压疾病患者血清sFlt-1表达水平升高,游离VEGF及NO表达水平降低,其升高与降低水平与病情轻重关系密切,参与妊娠期高血压疾病的发生发展。

The expresins of VEGF,SFLT-1, NO in the patients with hypertensive disorder complicating pregnancy.

Objective： We investigated the expressions of VEGF, sFlt-1 and NO in peripheral blood of patients with hypertensive disorder complicating pregnancy. Methods： 80 pregnant women were choosed as the research group who were regularly screening and delivered in weifang maternity and child care hospital. Disease group included 40 cases （gestational hypertension included 10 cases, mild preeclampsia included 15 cases, severe preeclampsia included 15 cases） . Normal pregnant women in control group included 40 cases. The expression level of VEGF, sFlt-1 and NO in serum were compared between the two groups. Results： 1. The results showed that the serum VEGF levels of disease group were relatively lower than those of control group （P〈0.05） ; the serum sFlt-1 levels of disease group were relatively higher than those of control group （P〈0.05） ; the serum NO levels of disease group were relatively lower than those of control group （P〈0.05） , and there were significant statistically differences. 2. The most obvious change of three kinds of factor was preeclampsia group. 3. There was a significant positive correlation between the sFIt-1/VEGF ratios in experimental group and the severity of the disease （P〈0.05） . There was a significant negative correlation between the NO concentration in experimental group and the severity of the disease （P〈0.05） . Conclusions. The sFlt-1 levels increased, the NO and VEGF levels decreased in hypertensive disorder complicating pregnancy comparing with the control group, the three factors correlated with disease severity. They played a role in the pathophysiology of hypertensive disorder complicating pregnancy.