Characterization and application of porous gold nanoparticles as 2‐photon luminescence imaging agents: 20‐fold brighter than gold nanorods |
| |
Authors: | Joo H. Park Jisoo Park Suho Kim Se‐Hwa Kim Tae G. Lee Jae Y. Lee Jung‐Sub Wi |
| |
Affiliation: | 1. Center for Optical Metrology, Korea Research Institute of Standards and Science, Daejeon, Republic of Korea;2. Center for Nano‐Bio Measurement, Korea Research Institute of Standards and Science, Daejeon, Republic of Korea |
| |
Abstract: | Two‐photon nonlinear microscopy with the aid of plasmonic contrast agents is an attractive bioimaging technique capable of generating high‐resolution images in 3 dimensions and facilitating targeted imaging with deep tissue penetration. In this work, physically synthesized gold nanoparticles containing multiple nanopores are used as 2‐photon contrast agents and are reported to emit a 20‐fold brighter 2‐photon luminescence as compared to typical contrast agents, that is, gold nanorods. A successful application of our porous gold nanoparticles is experimentally demonstrated by in vitro nonlinear optical imaging of adipocytes at subcellular level. |
| |
Keywords: | gold nanorods luminescence plasmonic porous nanoparticles 2‐photon |
|
|