| 7-氨基-3-无-3-头孢-4-羧酸的合成改进 |
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| 引用本文： | 齐永斌,吕健,张赫明. 7-氨基-3-无-3-头孢-4-羧酸的合成改进[J]. 河北化工, 2009, 32(10): 32-33 |
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| 作者姓名： | 齐永斌 吕健 张赫明 |
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| 作者单位： | 1. 石药集团河北中润制药有限公司,河北,石家庄,050041
2. 石药集团中奇制药技术(石家庄)有限公司,河北,石家庄,050051 |
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| 摘 要： | 为了改进7-ANCA的合成工艺,以7-苯乙酰氨-3-羟基-3-头孢-4-羧酸-二苯甲酯为原料,经还原、酯化、脱保护等反应合成了7-ANCA。结果显示,优化后的工艺成本较低,适合工业生产,总收率为56.0%,产品纯度达到98.0%。
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| 关 键 词： | 7-ANCA 合成 头孢母核 抗生素 |
Improved Synthesis of 7-Amino-3-cephem-4-carboxylic Acid |
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| QI Yong-bin,LV Jian,ZHANG He-ming. Improved Synthesis of 7-Amino-3-cephem-4-carboxylic Acid[J]. Hebei Chemical Engineering and Industry, 2009, 32(10): 32-33 |
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| Authors: | QI Yong-bin LV Jian ZHANG He-ming |
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| Affiliation: | QI Yong-bin, LV Jian, ZHANG He-ruing (1. CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd, Shijiazhuang 050051, China;2. CSPC Zhongrun Pharmaceu- tical Technology Co., Ltd, Shijiazhuang 050041, China) |
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| Abstract: | In order to improve the synthetic procedure of 7-ANCA,a cephalosporin nuclei,by the method of the target compound was synthesized from 7-phenyacetylamino-3-hydroxy-3-cepham-4-carboxylic acid diphenylmethy ester by the step of deoxidization,esterification,deprotection.The result show that the improveding synthetic procedure has the advantage of low cost and is suitable for industrial production and total yield was 56.0%,the product HPLC purity was more than 98%. |
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| Keywords: | 7-ANCA |
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