高效氟吡甲禾灵的合成

研究了以(R)-(+)-2-(4-羟基苯氧基)丙酸甲酯和2,3-二氯-5-三氟甲基吡啶为原料合成高效氟吡甲禾灵的后醚化方法。通过对溶剂、反应时间、反应温度等反应影响因素的研究,得出最佳合成条件。以N,N-二甲基乙酰胺为溶剂,碳酸钾为缚酸剂,在85℃下反应6 h以上,高效氟吡甲禾灵的收率为97.2%,e.e.值为98.4%。此方法具有产品成本更低、质量更好的优势。

Synthesis of Haloxyfop-P-methyl

Haloxyfop-P-methyl was synthesized by reaction of 2,3-dichlor-5-trifluoromethylpyridine and (R)-(+)-2-(4-hydroxyphenoxy)propanoate. The influences on reaction yield by solvent, reaction time and temperature were investigated. Thus the optimum process for the reaction was performed at the temperature of 85℃over the period of 6 h by using DMAC as solvent, and with potassium carbonate as base, resulting in 97.2% of yield with 98.4% value ofe.e.