C1q的沉积对V型狼疮性肾炎和原发性膜性肾病的鉴别诊断意义

目的:研究C1q在V型狼疮性肾炎、原发性膜性肾病及病理组织学为不典型膜性肾病肾活检标本中的沉积,分析其不同及意义。方法:对V型狼疮性肾炎、原发性膜性肾病和不典型膜性肾病的患者的肾活检组织进行C1q免疫组化染色,并收集临床和血清学指标,进行统计学分析。结果:V型狼疮性肾炎会出现C1q的沉积,原发性膜性肾病不会出现C1q的沉积,一些病理组织学表现不典型的膜性肾病,会出现C1q的沉积,后者阳性率与狼疮性肾炎接近,与膜性肾病相比,差异有统计学意义。结论:C1q阳性且病理组织学为不典型膜性肾病的患者,极有可能是早期的V型LN。

The Deposition of C_1q on Type V Lupus Nephritis and Primary Membranous Nephropathy Significance of Differential Diagnosis

Objective：To find out the difference and significance of the deposition of C1q in pure class V lupus nephritis,primary membranous nephropathy and atypical membranous nephropathy.Methods：C1q immunohistochemical staining for the pure class V lupus nephritis,membranous nephropathy and atypical membranous nephropathy was performed,and collected the clinical and Serological characteristics for the statistical analysis.Results：C1q deposited in the kidney of pure class V lupus nephritis,and not in the primary membranous nephropathy.Some patients with atypical membranous nephropathy could found out the deposition of C1q,the positive rate was approximated with pure class V lupus nephritis,and had significant difference with membranous nephropathy.Conclusion：Some patients with atypical membranous nephropathy and the deposition of C1q may be early pure class V lupus nephritis.