首页 | 官方网站   微博 | 高级检索  
     


Single cell clonotypic and transcriptional evolution of multiple myeloma precursor disease
Affiliation:1. Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;2. Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;3. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;4. Department of Internal Medicine, Section of Benign Hematology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;5. University of Southern California, Los Angeles, CA, USA;6. Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;7. The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, USA;1. Columbia Center for Translational Immunology, Irving Medical Center, New York, NY, USA;2. Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA;3. Department of Hematology Oncology, Columbia University Irving Medical Center, New York, NY, USA;4. Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA;5. Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA;6. Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA;7. Department of Neurosurgery, Stanford School of Medicine, Palo Alto, CA, USA;8. J.P. Sulzberger Columbia Genome Center, Columbia University, New York, NY, USA;9. Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA;10. Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA;11. Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA;12. Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, USA;13. Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA;14. Department of Pathology, UNC School of Medicine, Chapel Hill, NC, USA;1. Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA;2. Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL 60637, USA;3. Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA;4. Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA;5. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;6. The Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, Chicago, IL 600637, USA;7. Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China;8. Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany;9. State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;10. Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528437, China;11. Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA;1. Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA;2. Department of Otorhinolaryngology, Saarland University, Homburg, Germany;3. Breast Cancer Center, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA;1. CAS Key Laboratory of Tissue Microenvironment and Tumor, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health, Shanghai Jiao Tong University School of Medicine (SJTUSM) & Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China;2. Department of Urology, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing 400042, China;3. Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China;4. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;5. Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China;6. Department of Urology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai 200072, China;7. Department of Obstetrics, Gynecology and Pediatrics, West China Second University Hospital, Sichuan University, 20 Renmin South Road, Chengdu 610041, China;8. Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, 101 Longmian Avenue, Nanjing, Jiangsu 211166, China;9. State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China;1. Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland;2. Department of Pathology, University of Helsinki and HUS Diagnostic Center, Helsinki University Hospital, 00029 Helsinki, Finland;3. Cancer Invasion and Resistance Group, Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark;4. Cancer Research Unit, Institute of Biomedicine and FICAN West Cancer Centre, University of Turku, 20014 Turku, Finland;5. Department of Obstetrics and Gynaecology, University of Turku and Turku University Hospital, 200521 Turku, Finland;6. Biotech Research and Innovation Centre, University of Copenhagen, 2200 Copenhagen, Denmark;7. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark;1. Division of Molecular Pathology, the Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066CX Amsterdam, the Netherlands;2. Oncode Institute, Amsterdam, the Netherlands;3. Department of Molecular Oncology and Immunology, the Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066CX Amsterdam, the Netherlands;4. Department of Pathology, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081HV Amsterdam, the Netherlands;5. Division of Tumor Biology and Immunology, Oncode Institute, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands;6. Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, 3584CT Utrecht, the Netherlands;7. Division of Gene Regulation, the Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066CX Amsterdam, the Netherlands;8. Division of Cell Biology, the Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066CX Amsterdam, the Netherlands;9. Biostatistics Centre & Department of Psychosocial Research and Epidemiology, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands;10. Department of Human Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam UMC, 1105AZ Amsterdam, the Netherlands;11. Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Centre (UMC), 3584CT Utrecht, the Netherlands;12. Princess Maxima Center for Pediatric Oncology, 3584CT Utrecht, the Netherlands;13. Department of Pathology, Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands;14. Divisions of Molecular Pathology and of Medical Oncology, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands;15. Department of Pathology, University Medical Center, 1081HV Utrecht, the Netherlands;16. Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584CT Utrecht, the Netherlands;17. Netherlands Proteomics Center, 3584CT Utrecht, the Netherlands
Abstract:
><ol class=
  • Download : Download high-res image (208KB)
  • Download : Download full-size image
  • Keywords:single-cell RNA sequencing  multiple myeloma  monoclonal gammopathy of undetermined significance  smoldering multiple myeloma  single-cell B cell receptor sequencing  intra-tumoral heterogeneity  tumor microenvironment  tumor evolution  hyperdiploid  non-hyperdiploid
    本文献已被 ScienceDirect 等数据库收录!
    设为首页 | 免责声明 | 关于勤云 | 加入收藏

    Copyright©北京勤云科技发展有限公司    京ICP备09084417号-23

    京公网安备 11010802026262号