多囊卵巢综合征患者血清中一氧化氮水平及其相关因素的临床研究

目的探讨多囊卵巢综合征（PCOS）患者血清一氧化氮（NO）水平与其血管并发症的关系。方法采用硝酸还原酶法测定27例PCOS患者（PCOS组）,21例因男方因素或输卵管因素不孕患者（对照组）血清NO水平,测定并计算体重指数（BMI）、腰臀比（WHR）、收缩压（SBP）、舒张压（DBP）、体脂含量、胰岛素抵抗指数（HOMA-IR）、胰岛素敏感指数（IAI）、血清性激素、空腹血糖（FPG）和胰岛素（FINS）水平。结果非肥胖PCOS组的HOMA-IR高于非肥胖对照组,IAI、血清NO水平低于非肥胖对照组,差异均有显著性（P〈0.05）。非肥胖PCOS组IAI明显高于肥胖PCOS组,差异有显著性（P〈0.01）。血清NO水平在PCOS组和其对照组间差异无显著性（P〉0.05）。PCOS组中,血清NO水平与HOMA-IR（r=-0.317,P〈0.05）、体脂含量（r=-0.346,P〈0.05）呈负相关。结论PCOS患者血清NO水平降低,提示PCOS患者可能存在血管内皮功能受损。

Clinical study on the serum nitric oxide and related factors in women with PCOS

Objective To investigate the relationship between the serum nitric oxide(NO)and complications of angiocardiopathy in polycystic ovary syndrome(PCOS).Methods Twenty-seven patients with PCOS(15 in obese PCOS group,12 in non-obese PCOS group)and 21 normal women(10 in obese control group,11 in non-obese control group)were compared for BMI,WHR,SBP,DBP,body fat,HOMA-IR,IAI,as well as sera LH,FSH,E2,PRL,T,FINS,FPG and NO.Results Non-obese PCOS group has higher HOMA-IR than that in non-obese control group(P<0.05),but lower IAI and serum NO than that in non-obese PCOS group(P<0.05).No significant difference of serum NO in PCOS groups from their control groups was found.Serum NO was negatively correlated with body fat(r=-0.317,P<0.05),HOMA-IR(r=-0.346,P<0.05).Conclusions Patients with PCOS present endothelium dysfunction.Low level of serum NO is the early feature of endothelium dysfunction in PCOS.