Melatonin protects N2a against ischemia/reperfusion injury through autophagy enhancement |
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| Authors: | Yanchun Guo Jianfei Wang Zhongqiang Wang Yi Yang Ximing Wang Qiuhong Duan |
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| Affiliation: | 1. Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
2. Department of Emergency Medicine,Wuhan General Hospital of Guangzhou Command,Wuhan 430070,China |
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| Abstract: | Researches have shown that melatonin is neuroprotectant in ischemia/reperfusion-mediated injury.Although melatonin is known as an effective antioxidant,the mechanism of the protection cannot be explained merely by antioxidation.This study was devoted to explore other existing mechanisms by investigating whether melatonin protects ischemia/reperfusion-injured neurons through elevating autophagy,since autophagy has been frequently suggested to play a crucial role in neuron survival.To find it out,an ischemia/... |
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| Keywords: | melatonin autophagy ischemia/reperfusion rapamycin 3-MA LC3 Beclin1 PKB N2a |
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