| 雷公藤多甙对小鼠体内姐妹染色单体互换的影响 |
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| 引用本文： | 刘启兰,章子宁,钟昌奇,钱绍祯.雷公藤多甙对小鼠体内姐妹染色单体互换的影响[J].中国男科学杂志,1994(1). |
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| 作者姓名： | 刘启兰 章子宁 钟昌奇 钱绍祯 |
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| 作者单位： | 江苏省计划生育科学技术研究所
(刘启兰，章子宁，钟昌奇)，江苏省计划生育科学技术研究所(钱绍祯) |
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| 摘 要： | 雷公藤多甙(GTW)在雄性大鼠及男子均可致不育而无明显毒副作用。本实验用BABL/C小鼠骨髓细胞体内Brdu标记姐妹染色单体互换(SCE)的方法,测定GTW有无潜在的致突变作用。采用临床剂量3倍(3mg/kg)和100倍(100mg/kg),每天灌服,共 7天。另设阳性对照组一次性腹腔注射环磷酰胺30mg/kg。结果,SCE率范围低剂量组在1～7之间,平均值3.63±0.20(SE),高剂量组在1～15之间,平均值 4.56±0.39,阴性对照组在1～8之间,平均值 3.8±0.39,阳性对照组在 19～58之间,平均值33.1±1.06。经统计学处理,低、高剂量与阴性对照组之间无明显差异,而阳性对照组和其他各组之间均有显著性差异(P<0.01)。因而从本实验的结果来看,GTW似无诱变作用。
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| 关 键 词： | 雷公藤 致突变作用 姐妹染色单体互换 |
EFFECT OF TRIPTERYGIUM WILFORDII ON SISTER CHROMATID EXCHANGE IN MOUSE |
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| LIU Qi-Lan,ZHANG Zi-Ning,ZHONG Chang-Qi,QIAN Shao zhen. Jiangsu Family Planning Institute,Nanjing.EFFECT OF TRIPTERYGIUM WILFORDII ON SISTER CHROMATID EXCHANGE IN MOUSE[J].Chinese Journal of Andrology,1994(1). |
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| Authors: | LIU Qi-Lan ZHANG Zi-Ning ZHONG Chang-Qi QIAN Shao zhen Jiangsu Family Planning Institute Nanjing |
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| Affiliation: | LIU Qi-Lan,ZHANG Zi-Ning,ZHONG Chang-Qi,QIAN Shao zhen. Jiangsu Family Planning Institute,Nanjing 210029 |
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| Abstract: | The present investigation evaluated the possible mutagenic effect of GTW by means of observing the sister chromatid exchange (SCE) in bone marrow Cells of BABL/C mouse.GTW was given orally at dose levels of 3 times (3mg/ Kg.d)and 100 times(100mg/Kg.d)of the clinical dose for 7 days. In addition, recheck control and positive control (Cyclophosphamide 30mg/Kg).were arranged, Results showed that there were no significant difference between the low dose, high dose and the vehcle control groups, but a significant difference (P <0.01) was seen between the positive control group and each of other 3 groups. It is believed that GTWis not mutagenic so far as the results of the present experiment is considered. |
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| Keywords: | GTW Aberation Effect SCE |
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