| 3-氟-4-硝基苯酚的合成研究 |
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| 引用本文： | 郭瑞娟,陈玉琴,亓玲,张志德. 3-氟-4-硝基苯酚的合成研究[J]. 山东化工, 2011, 40(2): 20-22 |
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| 作者姓名： | 郭瑞娟 陈玉琴 亓玲 张志德 |
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| 作者单位： | 山东师范大学化学化工与材料科学学院,山东,济南,250014 |
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| 基金项目： | 山东省科技攻关项目资助 |
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| 摘 要： | 研究了以2，4-二氟硝基苯为原料，经甲氧基化、脱甲基化反应合成3-氟-4-硝基苯酚的新方法。探讨了反应条件对反应的影响：甲醇钠与2，4-二氟硝基苯物质的量比1：1，回流反应4h，得单氟代硝基苯甲醚；AlCl3与氟代硝基苯甲醚按物质的量比2．5：1在苯中回流反应10h，再经水蒸汽蒸馏分离提纯制得3-氟-4-硝基苯酚，质量分数99．5％，总收率38．7％。通过熔点测定、红外光谱和核磁共振等对产物结构进行了表征。
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| 关 键 词： | 3-氟-4-硝基苯酚 脱甲基化 合成 |
The Studies on Synthesis of 3-Fluoro-4-NitroPhenol |
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| GUO Rui-juan,CIIEN Yu-qin,QI Ling,ZHANG Zhi-de. The Studies on Synthesis of 3-Fluoro-4-NitroPhenol[J]. Shandong Chemical Industry, 2011, 40(2): 20-22 |
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| Authors: | GUO Rui-juan CIIEN Yu-qin QI Ling ZHANG Zhi-de |
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| Affiliation: | GUO Rui-juan,CHEN Yu-qin,QI Ling,ZHANG Zhi-de(College of Chemistry,Chemical Engineering and Materials Science,Shandong Normal University,Jinan 250014,China) |
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| Abstract: | 3-Fluoro-4-nitrophenol was synthesized from 2,4-difluoronitrobenzene by the methoxylation and demethylation.The influencing factor of the reaction was studied: the monosubstitued fluoro-nitroanisole was synthesized with mole ratio of sodium methoxide and 2,4-difluoronitrobenzene was 1:1,refluexing reaction time 4h in methanol;3-fuoro-4-nitrophenol was synthesized with mole ratio of aluminium chloride and monosubstitued fluoro-nitroanisole was 2.5:1,refluexing reaction time 10h in benzene,and purified by ste... |
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| Keywords: | 3-fluoro-4-nitro-phenol demethylation synthesis |
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