新型生物医用材料: 肽类树枝状大分子及其生物医学应用

肽类树枝状大分子是近年来发展起来的一类新型生物医用高分子材料, 它在具有普通树枝状大分子的特征如规整性、高度支化、表面呈现高密度功能团、尺度为纳米级、通过可控制备可得到单一分子量等之外, 同时还具有类似蛋白一样的球状结构、好的生物相容性、水溶性、耐蛋白酶水解、生物降解等独特的性能. 肽类树枝状大分子的上述特点, 使其在生物医学应用中显示出诱人的前景. 本综述从肽类树枝状大分子的制备出发、详尽介绍了肽类树枝状大分子的功能化及其在疾病诊断和治疗中的应用等方面的研究进展, 籍此推动肽类树枝状大分子在生物医学领域的研究与开发.

New-generation biomedical materials:peptide dendrimers and their application in biomedicine

Peptide dendrimers are attractive synthetic polymers and have been widely used as a new generation of biomaterials in recent years.Peptide dendrimers,as well as general dendrimers,may be synthesized to reach nano sizes,and display well-defined architectures,highly-branched structures,high density of functional terminal groups,and controllable molecular weights.On the other hand,peptide dendrimers have properties similar to proteins and some special characteristics,such as good biocompatibility,water solubil...