| 7-(4-氯苄基)-7,8,13,13a-四氢小檗碱在家兔体内的代谢产物分析 |
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| 引用本文： | 冯年平,张正行,安登魁,韩秀文,黄文龙,王广基. 7-(4-氯苄基)-7,8,13,13a-四氢小檗碱在家兔体内的代谢产物分析[J]. 药学学报, 2001, 36(2): 137-139 |
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| 作者姓名： | 冯年平 张正行 安登魁 韩秀文 黄文龙 王广基 |
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| 作者单位： | [1]中国药科大学，江苏南京２１０００９ [2]中国科学院大连化学物理研究所，辽宁大连１１６０２３ |
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| 摘 要： | AIM To explore the biotransformation of compound 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine in the rabbit. METHODS Analyze the rabbit bile sample with HPLC, LC/MS and LC/NMR. RESULTS A metabolite and unchanged 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine were found in the rabit bile, the metabolite was characterized and its structure was elucidated. CONCLUSION Compound 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine is metabolized by demethylation at 10-OCH3 position.
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| 关 键 词： | 7-(4-氯苄基)-7,8,13,13a-四氢小檗碱 高效液相色谱法 LC/MS LC/NMR 代谢产物 |
| 收稿时间： | 2000-07-19 |
ANALYSIS OF THE METABOLITE OF 7-(4-CHLORBENZYL)-7,8,13,13a-TETRAHYDROBERBERINE IN RABBIT |
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| FENG Nian-ping,ZHANG Zheng-xing,AN Deng-kui,HAN Xiu-wen,HUAN Wen-long,WANG Guang-ji. ANALYSIS OF THE METABOLITE OF 7-(4-CHLORBENZYL)-7,8,13,13a-TETRAHYDROBERBERINE IN RABBIT[J]. Acta pharmaceutica Sinica, 2001, 36(2): 137-139 |
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| Authors: | FENG Nian-ping ZHANG Zheng-xing AN Deng-kui HAN Xiu-wen HUAN Wen-long WANG Guang-ji |
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| Affiliation: | China Pharmaceutical University, Nanjing 210009, China. npfeng@citiz.net |
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| Abstract: | AIM: To explore the biotransformation of compound 7-(4-chlorbenzyl)-7,8,13, 13a-tetrahydroberberine in the rabbit. METHODS: Analyze the rabbit bile sample with HPLC, LC/MS and LC/NMR. RESULTS: A metabolite and unchanged 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine were found in the rabit bile, the metabolite was characterized and its structure was elucidated. CONCLUSION: Compound 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine is metabolized by demethylation at 10-OCH3 position. |
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| Keywords: | HPLC LC/MS LC/NMR Metabolite 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine |
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