| 基于Oncomine数据库荟萃分析COL1A2在胃癌患者中的表达及其临床意义 |
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| 引用本文： | 肖毓,张洪攀,谭榜宪.基于Oncomine数据库荟萃分析COL1A2在胃癌患者中的表达及其临床意义[J].肿瘤预防与治疗,2019,32(6):503-510. |
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| 作者姓名： | 肖毓 张洪攀 谭榜宪 |
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| 作者单位： | 川北医学院 |
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| 摘 要： | 目的:通过对Oncomine数据库进行挖掘,分析Ⅰ型胶原α2链(collagen type1 alpha2,COL1A2)基因在胃癌中的表达及其临床意义。方法:收集Oncomine数据库中COL1A2基因在胃癌组织中的表达信息,并进行荟萃分析。利用Kaplan Meier-Plotter进行患者生存周期分析。使用基于TCGA数据集的UALCAN在线数据库对COL1A2在胃癌患者中的表达及预后进行验证。结果:Oncomine数据库中共收集了有关COL1A2表达在348项不同肿瘤中的研究结果,其中关于COL1A2表达有统计学差异的研究结果有102个。有9项研究显示COL1A2在胃癌组织与正常组织中的表达有差异,包括478个样本,荟萃分析发现,与正常胃组织相比,COL1A2在胃癌组织中高表达,差异有统计学意义(P<0.001)。生存分析显示COL1A2表达量与胃癌患者总体生存率存在相关性,高表达COL1A2的患者总体生存期较低表达者缩短(P<0.001)。亚组分析发现,高表达COL1A2的肠型胃癌患者的总体生存期较低表达者缩短(P<0.001)。TCGA数据集验证显示COL1A2在胃癌组织中的表达量与预后相关。结论:COL1A2基因在胃癌中高表达,且其表达水平与胃癌患者总体生存相关。COL1A2是与胃癌预后相关的生物标志物,有望成为胃癌精准治疗的靶点。
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| 关 键 词： | COL1A2 胃癌 Oncomine TCGA |
Expression of COL1A2 in Gastric Cancer and Its Clinical Significance: Analysis Based on Data Mining of Oncomine |
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| Xiao Yu,Zhang Hongpan,Tan Bangxian.Expression of COL1A2 in Gastric Cancer and Its Clinical Significance: Analysis Based on Data Mining of Oncomine[J].Journal of Cancer Control and Treatment,2019,32(6):503-510. |
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| Authors: | Xiao Yu Zhang Hongpan Tan Bangxian |
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| Affiliation: | (School of Clinical Medicine,North Sichuan Medical College,Nanchong 637000,Sichuan,China;School of Medical Imaging,North Sichuan Medical College,Nanchong 637000,Sichuan,China;Department of Oncology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China) |
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| Abstract: | Xiao Yu;Zhang Hongpan;Tan Bangxian(School of Clinical Medicine,North Sichuan Medical College,Nanchong 637000,Sichuan,China;School of Medical Imaging,North Sichuan Medical College,Nanchong 637000,Sichuan,China;Department of Oncology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China) |
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| Keywords: | COL1A2 Gastric cancer Oncomine TCGA |
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