AAX14401蛋白在人膀胱癌组织中的表达及其意义

目的：研究AAX14401蛋白在正常膀胱组织和膀胱移行细胞癌组织中的表达情况，分析其在膀胱癌发生发展过程中的作用。方法：收集膀胱癌组织标本75例作为实验组，以正常膀胱黏膜组织12例作为对照组，应用免疫组织化学法检测谷胱甘肽S转移酶P1（GSTP1）和AAX14401的阳性表达率，分析GSTP1和AAX14401蛋白阳性表达率在膀胱癌组织和正常膀胱组织中的差异。结果：正常膀胱组织中GSTP1蛋白阳性表达率为58.3%，膀胱癌组织中GSTP1蛋白阳性表达率为90.7%，二者比较差异有统计学意义（P<0.01）；在正常膀胱组织中AAX14401蛋白表达均为阴性，在膀胱癌组织中AAX14401蛋白阳性表达率为2.7%，二者比较差异无统计学意义（P=0.596）；膀胱癌组织中AAX14401蛋白和GSTP1蛋白无同为阳性表达者，GSTP1阴性表达的膀胱癌组织中有2例Anti-AY阳性表达，GSTP1蛋白与AAX14401蛋白在膀胱癌组织中阳性表达呈负相关关系（r=-0.274，P=0.018）。结论：AAX14401蛋白在膀胱癌中的表达可能促进了膀胱癌的发生发展。

Expression of AAX14401 in human bladder cancer tissue and its significance

Objective:To study the expressions of AAX14401 in the normal bladder tissueand the human bladder transitional cell carcinoma tissue, and to analyze its function in the occurrence and development of bladder cancer. Methods:Seventy-five cases of specimens of bladder transitional cell carcinoma were collected and used as experimental group and 12 cases of normal bladder mucosa specimens were selected as control group. The positive expression rates of glutathione S-transferase pi-1(GSTP1) and AAX14401 were detected by immunohistochemistry. The differences of positive expression rates of GSTP1 and AAX14401 proteins between bladder cancer tissue and normal bladder tissue were analyzed. Results:The positive expression rate of GSTP1 protein in normal bladder tissue was 58.3%, while it was 90.7% in bladder cancer tissue, and the difference between them was significant (P<0.01). The positive expression rate of AAX14401 protein in normal bladder tissue was 0%, while it was 2.7% in blandder cancer tissue, and there was no significant difference between them(P=0.596). There was no one with positive AAX14401 expression and positive GSTP1 expression in bladder cancer tissue at the same time. There were 2 cases with positive AAX14401 expression in bladder cancer tissue with negative GSTP1 expression; there was a negative correlation between the positive expressions of AAX14401 and GSTP1 proteins in bladder cancer (r=-0.274, P=0.018). Conclusion:The expression of AAX14401 protein may promote the incidence and progression of bladder cancer.