胃癌组织中ZAC与生长抑素表达的相关性

目的 研究胃癌组织中ZAC和生长抑素表达的相关性,探讨胃癌组织中ZAC与生长抑素的表达与胃癌临床病理学特性的关系.方法 应用免疫组织化学技术检测30例胃癌患者手术切除标本及其相应癌旁组织和正常胃黏膜组织中ZAC和生长抑素的表达.结果 胃癌、癌旁及正常胃黏膜组织中ZAC的阳性表达率分别为33.3%(10/30)、73.3%(22/30)和66.7%(20/30);生长抑素的阳性表达率分别为36.7%(11/30)、53.3%(16/30)和73.3%(22/30).胃癌组织中ZAC和生长抑素的表达阳性率均明显低于正常胃黏膜组织(均P<0.05).胃癌组织中ZAC与生长抑素的表达呈明显正相关(r=0.636,P<0.05).ZAC与生长抑素的共表达与胃癌的分化程度及浸润深度有明显关系(P<0.05),而与淋巴结转移无明显关系(P>0.05).结论 胃癌组织中ZAC与生长抑素的表达具有明显相关性,生长抑素可能与ZAC协同参与胃癌的发生和发展.

Correlation of ZAC and somatostatin expression in gastric cancer tissues.

Objective To study the correlation of ZAC and somatostatin (SST) expression in gastric cancer tissues, and explore the relationship between expression of ZAC and SST with clinicopethological factors of gastric cancer,and the correlation between ZAC and SST. Methods Immunohistochemistry was performed to detect the ex-pression of ZAC and SST in gastric cancer tissues (n =30 cases) ,gastric tissues adjacent to cancer and normal gas-tric mucosa tissues. Results The positive rate of ZAC in gastric cancer tissues, gastric tissues adjacent to cancer and normal gastric mucosa tissues was 33.3 % (10/30) ,73.3 % (22/30) and 66.7 % (20/30) respectively; that of SST was 36.7% (11/30) ,53.3% (16/30) and 73.3% (22/30) respectively. The positive rates of beth ZAC and SST in gastric cancer tissues were significantly lower than those in normal gastric mucosa tissues (P < 0.05). ZAC expres-sion was positively correlated with SST expression in gastric cancer tissues (r = 0. 636 ,P < 0.05). Co-expression of ZAC and SST was obviously related to differentiation type and infiltration degree (P <0.05). However,no relation was found between co-expression of ZAC and SST and lymph node metastasis (P > 0.05). Conclusion ZAC is sig-nificantly correlated with SST in gastric cancer tissues. SST and ZAC may be involved in the development and pro-gression of gastric cancer.