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| 壳聚糖微球的纤毛毒性和黏附力的考察 | |
| 引用本文： | 赵磊,姜斌,王铭远,郝睿,郑爱萍,武凤兰. 壳聚糖微球的纤毛毒性和黏附力的考察[J]. 中国医院药学杂志, 2005, 25(8): 697-699 |
| 作者姓名： | 赵磊 姜斌 王铭远 郝睿 郑爱萍 武凤兰 |
| 作者单位： | 1. 河北工程学院医学部,河北,邯郸,05602 2. 邯郸市第一医院,河北,邯郸,056002 3. 北京大学药学院,北京,100083 |
| 摘 要： | 目的:考察鼻黏膜用壳聚糖微球的纤毛毒性及黏附力.方法:采用在体蟾蜍上腭纤毛试验法,通过测定纤毛摆动持续时间评价微球制剂的鼻纤毛毒性,测定纤毛输送速率评价微球的黏膜黏附力.结果:壳聚糖微球能显著地降低鼻纤毛毒性,并且具有良好的生物黏附性.结论:壳聚糖是理想的鼻腔给药系统的载体材料. |
| 关 键 词： | 壳聚糖 微球 纤毛毒性 黏附力 |
| 文章编号： | 1001-5213(2005)08-0697-03 |
| 收稿时间： | 2004-09-20 |
| 修稿时间： | 2004-09-20 |
Study on ciliotoxicity and mucoadhesion of chitosan microspheres |
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| ZHAO Lei,JIANG Bin,WANG Ming-yuan,Hao Rui,ZHENG Ai-ping,WU Feng-lan. Study on ciliotoxicity and mucoadhesion of chitosan microspheres[J]. Chinese Journal of Hospital Pharmacy, 2005, 25(8): 697-699 | |
| Authors: | ZHAO Lei JIANG Bin WANG Ming-yuan Hao Rui ZHENG Ai-ping WU Feng-lan |
| Affiliation: | 1. Handan Medical College, Hebei Handan 056002, China; 2. The First Hospital of Handan, Hebei Handan 056002,China;3. School of Pharmaceutical sciences, Peking University, Beijing 100083,China |
| Abstract: | OBJECTIVE To study the ciliotoxicity and mucoadhesion of chitosan microspheres.METHODS To evaluate the ciliotoxicity of 5-Fu-loaded chitosan microspheres , the lasting time of ciliary movement was recorded with in situ toad palate model. The degree of mucoadhesion was also investigated by determining the mucociliary transport rate(MTR) of the microspheres across a toad palate.RESULTS Chitosan microsphere could effectively reduce ciliotoxicity and had a good mucoadhesive property. CONCLUSION Chitosan is a good material for intranasal drug delivery. |
| Keywords: | chitosan microspheres ciliotoxicity mucoadhesion |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
