微流控芯片液滴生成与检测技术研究进展

微流控芯片液滴技术是一种操控微小体积液体的新技术,既可实现高通量微观样本的生成及控制,也可进行独立液滴的操作.分散的微液滴单元可作为理想的微反应器,在生物医药中的药物筛选、材料筛选和高附加值微颗粒材料合成领域展现出巨大的应用潜力.液滴微流控芯片是利用流体剪切力的改变,使互不相溶的两相流体在其界面处生成稳定、有序的液滴,...

Research Progress of Droplet Generation and Detection Technology of Microfluidic Chip

The microfluidic chip droplet technology is a new technology for manipulating tiny volumes of liquids,which can realize the generation and control of high-throughput microscopic samples,as well as the operation of independent droplets.The dispersed micro-droplet unit can be used as an ideal micro-reactor,showing great application potential in the fields of drug screening,material screening and high value-added micro-particle material synthesis in biomedicine.The droplet microfluidic chip uses the change of the fluid shear force to make the immiscible two-phase fluid generate stable and ordered droplets at its interface.The current generation methods of microdroplets mainly include hydrodynamic methods,pneumatic method,light control method and electric method,etc.Droplet-based microfluidic systems are increasingly used to perform complex multiple reactions,measurements and analyses,and can perform ultra-small volume and ultra-high throughput chemical and biological experiments.For the droplet microfluidic system,the speed,size and content of the droplet will affect the final inspection result.Therefore,the real-time detection of the droplet formation rate and the content of the droplet is very important,and it is most commonly used at present.The droplet detection methods include optical detection technology and electrical sensing detection technology.The two-phase flow droplet generation mechanism and the existing droplet generation technology are discussed and analyzed,and the droplet detection technology is also reviewed.