| 溴酸盐的遗传毒性 |
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| 引用本文： | 王伟,蒋颂辉,朱惠刚,王一璞,杨艳. 溴酸盐的遗传毒性[J]. 环境与健康杂志, 2003, 20(3): 137-138 |
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| 作者姓名： | 王伟 蒋颂辉 朱惠刚 王一璞 杨艳 |
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| 作者单位： | 复旦大学公共卫生学院,上海,200032 |
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| 摘 要： | 目的 探讨臭氧消毒饮用水副产物溴酸盐的遗传毒性。方法 采用Ames试验、UDS试验和微核试验，从基因水平、DNA水平和染色体水平对臭氧消毒副产物溴酸盐的遗传毒性进行研究。结果与阴性对照组相比，副产物溴酸盐不能使组氨酸缺陷型鼠伤寒沙门菌回复突变增加，但可使大鼠肝细胞程序外DNA合成增加和小鼠骨髓嗜多染红细胞微核形成率增加。结论 臭氧消毒副产物溴酸盐可能具有DNA及染色体水平的遗传毒性。
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| 关 键 词： | 溴酸盐 饮用水 臭氧 消毒副产物 遗传毒性 |
| 文章编号： | 1001-5914(2003)03-0137-02 |
| 修稿时间： | 2002-11-25 |
Study on the Genotoxicity of Bromate |
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| WANG Wei,JIANG Song-hui,ZHU Hui-gang,et al.. Study on the Genotoxicity of Bromate[J]. Journal of Environment and Health, 2003, 20(3): 137-138 |
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| Authors: | WANG Wei JIANG Song-hui ZHU Hui-gang et al. |
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| Affiliation: | WANG Wei,JIANG Song-hui,ZHU Hui-gang,et al.School of Public Health,Fudan University,Shanghai 200032,China |
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| Abstract: | Objective To study the genotoxicity of bromate,a chief by-product of ozonated drinking water.Methods Genotoxicity at gene,DNA and chromosome levels induced by bromate DBP was determined using Ames test,unscheduled DNA synthesis(UDS)assay and micronucleus test(MNT)of mice bone marrow polychromatic erythrocytes respectively.Results In Ames test,bromate showed no mutagenic effect on salmonella typhimurium TA98and TA100strains with or without S9(rat liv-er metabolic activation system)compared with the negative control group,but the results of UDS assay showed that bromate could induce unscheduled DNA synthesis in rat primary hepatocytes and the results of MNT indicated that bromate increased the micronucleus rate of bone marrow polychromatic erythrocytes of mice.Conclusion It was suggested that bromate DBP might have genotoxicity at DNA and chromosome levels. |
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| Keywords: | Bromate Drinking water Ozone Disinfection by-product(DBP) Genotoxicity |
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