C反应蛋白和2型糖尿病及大血管病变的相关性研究

目的：探讨C反应蛋白与2型糖尿病大血管病变发生的关系。方法：将70例T2DM分为合并大血管并发症组（33例）与无大血管并发症组（37例），正常对照组（35例）。对所有纳入对象测定血脂、糖化血红蛋白和CRP水平。结果：2型DM患者的CRP水平明显高于正常对照组（P〈0．05），其中有大血管并发症组显著高于无大血管并发症组（P〈0．05），Logstic回归分析显示，CRP水平可能是T2DM患者大血管并发症发生的独立危险因素。结论：CRP与2型DM的发生相关，升高的CRP可能是促使T2DM并发大血管病变的独立危险因素。

C-REACTIVE PROTEIN LEVEL AND MACROANGIOPATHY IN PATIENTS WITH TYPE 2 DIABETES

Objective： To explore the association between c-reactive protein（CRP） level and macroangiopathy in type 2 diabetic patients.Methods： Seventy diabetic patients and thirty-five normal were divided into three groups. Patient with macroangiopathy, without macroangiopathy, and normal control .Hemoglobin Alc （HbAlc）, total cholesterol（TC）, trlglycerides（TG） and sensitivity CRP were assessed. Results： Level of CRP was different in three groups significantly （P〈0.05）. The CRP level of patient with maeroangiopathy group was increased more than that of patient without maeroangiopathy group（P〈0.05）. Logstic regression analysis revealed that the level of CRP was probably the independent risk factor to macroangiopathy in T2DM patient. Conclusion： CRP is associated with the development of type 2 diabetes.Increased CRP is probably an independent risk factor of diabetic macroangiopathy in type 2 diabetes.