| 外泌体在恶性胶质瘤诊治中的研究现状及进展 |
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| 引用本文： | 唐邵华,阴骏,王卫东,郞锦义. 外泌体在恶性胶质瘤诊治中的研究现状及进展[J]. 中华放射肿瘤学杂志, 2018, 27(4): 425-429. DOI: 10.3760/cma.j.issn.1004-4221.2018.04.019 |
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| 作者姓名： | 唐邵华 阴骏 王卫东 郞锦义 |
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| 作者单位： | 646000 泸州,西南医科大学临床医学院(唐邵华、郞锦义);610041成都,四川省肿瘤医院·研究所 四川省癌症防治中心放疗科电子科技大学医学院(唐邵华、阴骏、王卫东、郞锦义) |
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| 基金项目： | 四川省人力资源和社会保障厅学术和技术带头人培养项目(2016RS0026);四川省卫生和计划生育委员会普及应用项目(16PJ511) |
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| 摘 要： | 近年来,外泌体逐渐成为肿瘤研究的热点,外泌体在肿瘤增殖、分化、转移等多个方面发挥着重要的作用。同时,外泌体具有纳米级大小的特点,因此可以通过血脑屏障,使其可能成为恶性胶质瘤新的诊治手段。该文通过复习57篇文献,将外泌体在恶性胶质瘤发生发展、液体活检、预后评估、治疗中的应用研究现状及进展作一综述。
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| 关 键 词： | 外泌体 胶质瘤 液体活检 预后评估 |
| 收稿时间： | 2017-07-13 |
Research status and progress on exosomes in the diagnosis and treatment of malignant glioma |
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| Tang Shaohua,Yin Jun,Wang Weidong,Lang Jinyi. Research status and progress on exosomes in the diagnosis and treatment of malignant glioma[J]. Chinese Journal of Radiation Oncology, 2018, 27(4): 425-429. DOI: 10.3760/cma.j.issn.1004-4221.2018.04.019 |
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| Authors: | Tang Shaohua Yin Jun Wang Weidong Lang Jinyi |
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| Affiliation: | Southwest Medical University,Luzhou 646000,China (Tang SH);Department of Radiotherapy,Sichuan Cancer Hospital& Institute,Sichuan Cancer Center,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610041,China (Tang SH,Yin J,Wang WD,Lang JY) |
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| Abstract: | In recent years, exosomes has gradually captivated widespread attention. It plays a crucial role in the proliferation, differentiation and metastasis of malignant tumors. As nanosized vesicles,exosomes can penetrate through the blood-brain barrier. Thus,exosomes may be a novel tool for the diagnosis and treatment of malignant glioma. In this paper, 57 relevant literatures were reviewed to summarize the research status and progress on the role of exosomes in the incidence, progression, liquid biopsy, prognosis evaluation and clinical therapy of malignant glioma. |
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| Keywords: | Exosomes Glioma Liquid biopsy Prognosis evaluation |
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