幽门螺杆菌感染与结直肠癌相关性的研究

  目的  探讨幽门螺杆菌（Helicobacter pylori，Hp）感染与结直肠癌的相关性。  方法  分析2015年6月至2020年6月郑州大学第一附属医院诊治的70例结直肠癌患者，选取同期于本院体检的99例健康体检者为对照组，应用13C尿素呼气试验检测结直肠癌组与对照组的Hp感染率。  结果  对照组Hp阳性51例，阳性率51.52%；结直肠癌组Hp阳性47例，阳性率67.14%，结直肠癌组的Hp阳性率明显高于正常对照组，差异具有统计学意义（P < 0.05）。单因素分析发现，Hp感染为结直肠癌的独立危险因素（OR=1.923，95% CI:1.019~3.632；P < 0.05）。结直肠癌患者中，高-中分化组和低分化组患者的Hp感染率分别为54.29%和80.00%，两组比较差异具有统计学意义（P < 0.05）；临床分期为Ⅰ~Ⅱ期组和Ⅲ~Ⅳ期组患者的Hp感染率分别为52.00%和75.56%，两组比较差异具有统计学意义（P < 0.05）；然而Hp感染率在结直肠癌患者的性别、年龄、部位、形态、微卫星状态及病理分型等各分组内的差异无统计学意义（P>0.05）。  结论  Hp感染可能是结直肠癌发生发展的危险因素。 

Relationship between Helicobacter pylori infection and colorectal cancer

Objective:To assess the correlation between Helicobacter pylori(Hp)infection and colorectal cancer.Methods:Seventy patients with colorectal cancer who were diagnosed and treated at The First Affiliated Hospital of Zhengzhou University from June 2015 to June 2020 were selected as research participants and 99 healthy individuals who underwent physical examinations at this hospital during the same period were selected as controls.The 13C urea breath test was used to detect the Hp infection rate in the colorectal cancer and control groups.Results:Fifty-one(51.52%)and 47(67.14%)cases were positive for Hp in the control and colorectal cancer groups,respectively.The Hp-positive rate was significantly higher in the colorectal cancer group than in the control group(P<0.05).Univariate analysis of the colorectal cancer and control groups showed that Hp infection was an independent risk factor for colorectal cancer(odds ratio=1.923,95% confidence interval:1.019-3.632,P<0.05).Among patients with colorectal cancer,the Hp infection rates in the high-medium and poorly differentiated groups were 54.29%and 80.00%,respectively,and the difference was statistically significant(P<0.05).The Hp infection rates of patients with clinical stagesⅠ-Ⅱand those with clinical stagesⅢ-Ⅳwere 52.00% and 75.56%,respectively,and the difference was statistically significant(P<0.05).However,there was no statistically significant difference in the Hp infection rates among patients with colorectal cancer in terms of sex,age,location,morphology,microsatellite status,and pathological classification(P>0.05).Conclusions:Hp infection may be a risk factor for the occurrence and development of colorectal cancer.