粪乳铁蛋白和C 反应蛋白对溃疡性结肠炎的评价

目的:研究粪乳铁蛋白(1actoferrin,LF)和C反应蛋白(C-reactive protein,CRP)对溃疡性结肠炎的严重程度、活动性和对治疗反应的评价作用。方法:选取我院2009-2010年43例特发性溃疡性结肠炎患者,同时进行对照平行研究。对患者进行临床评估、内镜和病理检查,了解疾病活动性、严重程度,并检测LF、CRP在治疗前后的水平。结果:与对照组相比较,病例组生物学标志都升高(P=0.000),特发性溃疡性结肠炎严重组粪LF和CRP更高,治疗后,生物学指标下降到与Mayo分数齐平,ROC曲线下面积分别为0.953和0.721,其灵敏度和特异性分别为:LF(90.7%,100%)和CRP(44.2%,100%)。结论:在对特发性溃疡性结肠炎的活动性、严重程度和对治疗反应的评价中,粪LF和CRP是非常有用的生物学指标。

Fecal Lactoferrin and Serum C-reactive Protein for the Assessment in Ulcerative Colitis

Objective: To examine the role of serum C-reactive protein(CRP),and fecal lactoferrin(LF) in assessing ulcerative colitis(UC) severity,activity and response to therapy.Methods: 43 consecutive patients with UC attending our hospital from 2009 to 2010 were studied.An equal number of healthy age-matched controls were studied for biomarker levels.All underwent clinical,endoscopic and histological assessment for disease activity,extent,severity and estimation of CRP and LF levels at baseline and follow up.Results: The both biomarkers were elevated more often in the cases than in the controls(all P = 0.000).Cases with severe UC had higher CRP and LF titers than those without severe IUC.After treatment,a significant fall in biomarker levels paralleled the reduction in Mayo’s scores.The areas under the curve for LF and CRP were 0.953 and 0.721,respectively.The sensitivity and specificity of markers were: LF(90.7%,100%),and CRP(44.2%,100%).Conclusion: The both biomarkers are useful in assessing disease activity,severity and response to therapy in patients with UC.