青霉素每日序贯给药与常规静滴疗法217例的成本-效果分析

目的:分析比较青霉素每日序贯给药与常规静滴疗法治疗呼吸道轻、中度感染的成本和效果,为临床青霉素静滴中的不合理用药提供新的改进方法。方法:选取需静滴给药的轻、中度呼吸道感染患者,随机分为序贯法治疗组(青霉素id. po.)和常规法治疗组(id.)进行试验,有效病例分别为112例、105例。采用直接成本的成本-效果分析法对试验结果进行分析,并对其间接成本和隐性成本作比较讨论。结果:两种方法的有效率分别为91·0%和94·3%(P>0.05)。序贯治疗组的成本效果比(2·04)小于常规治疗组(3·11),且在统计学上差异显著(P<0.05)。结论:青霉素每日序贯给药与常规静滴疗法治疗呼吸道轻、中度感染疗效相当,但在降低治疗的成本上具有优势。

Cost-effectiveness analysis of daily sequential administration and routine intravenous drip therapy with penicillin in 217 patients with upper respiratory tract infection

Objective: To compare the cost-effectiveness of daily sequential administration and routine intravenous drip therapy with penicillin in patients with upper respiratory tract infection, and provide a new method for rational use of penicillin. Methods: Patients with upper respiratory tract infection were divided into two groups: daily sequential administration group (penicillin,ivd. po.,112 patients) and routine intravenous drip therapy group (penicillin,ivd., 105 patients). The results of different administration methods were analyzed using direct cost-effectiveness analysis method, including discussion of indirect cost and recessive cost. Results: Effective rates of two groups were 91.0% and 94.3%, respectively (P>0.05). Cost-effectiveness ratio of daily sequential administration group (2.04) was lower than that of routine intravenous drip therapy group (3.11)(P<0.05). Conclusion: Daily sequential administration has lower cost-effectiveness ratio in treatment of patients with upper respiratory tract infection. It may be a choice to use penicillin rationally and economically.