| ~(18)F标记正电子药物研究现状与进展 |
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| 引用本文： | 霍焱,王荣福.~(18)F标记正电子药物研究现状与进展[J].核化学与放射化学,2015,37(5):376-380. |
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| 作者姓名： | 霍焱 王荣福 |
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| 作者单位： | 北京大学 第一医院，北京100034 |
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| 摘 要： | <正>电子发射断层显像在肿瘤受体研究中,用18F标记精氨酰-甘氨酰-天冬氨酸(arg-gly-asp,RGD)肽靶向肿瘤组织内新生血管内膜细胞和肿瘤细胞膜上高表达的αvβ3整合素以揭示血管生成、肿瘤生长和转移,已成为近些年研究的热点和难点,而其研究进展在一定程度上也反映了18 F标记多肽的发展历程。本文就目前国内外18F标记正电子药物的研究现状与进展进行综述。
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| 关 键 词： | 正电子发射断层成像（PET) 18F标记 精氨酰-甘氨酰-天冬氨酸 &alpha v&beta 3 化学合成法 |
Current Researches and Progress on Preparation of 18F Labeled Positron Radiopharmacueticals |
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| HUO Yan,WANG Rong-fu.Current Researches and Progress on Preparation of 18F Labeled Positron Radiopharmacueticals[J].Journal of Nuclear and Radiochemistry,2015,37(5):376-380. |
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| Authors: | HUO Yan WANG Rong-fu |
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| Affiliation: | Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China |
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| Abstract: | In the tumor receptor researches by positron emission tomography, fluorine 18F-labeled RGD peptides target αvβ3 integrin which is highly expressed in tumor angiogenesis and tumor endometrial cells, and thus can reveal tumor angiogenesis, proliferation and metastasis. The relative researches are recently highlighted and focused, meanwhile present the progress of 18F labeled small peptides. In this review, current researches and progress on the preparation of 18F labeled positron radiophamaceuticals will be introduced. |
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| Keywords: | positron emission tomography 18 RGD v chemical synthesis |
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