邻醌式同系物的DSC研究

丹参(Salvia miltirrohiza)和红根草(S.Prionitis)均含有治疗冠心病有效成分—丹参酮Ⅱ-A等二萜醌类化合物,它们的扩冠作用,抑制血小板聚集,抑菌等活性常与该类化合物的结构、晶型、极性、溶解度、熔点有密切的相关性,如前报所述A环为脂环的化合物其熔化热低于芳环的化合物.丹参中的丹参醌Ⅱ-A(1),丹参醌Ⅱ-B(2)和红根草邻醌(3),其抗菌和抗肿瘤活性强度是3>2>1,为探究其晶型结构与药效的内在联系,本文对该类化

STUDY ON O-QUINONOID FORM HOMOLOGUES BY DSC

This paper presents the study on thermodynamic characteristics of phase transitions for tanshinone Ⅱ-A, tanshinone Ⅱ-B and saprorthoquinone (hereafter abbreviated to 1,2 and 3 respectively) by Differential Scanning Calorimetry (DSC). The relationships of their molecular structures with thermodynamic parameters were discussed. The experimental results obtained are listed in Table 2. The differences of nominated compounds for their melting points, melting enthalpies and melting entropies are as follows:T_m~1>T_m~3, ΔH_m~1>ΔH_m~3, ΔS_m~1=ΔS_m~3;T_m~1>T_m~2, ΔH_m~1>ΔH_m~2, ΔS_m~1=ΔS_m~2.