428例慢性前列腺炎病原学检查及其临床意义

目的研究慢性前列腺炎与病原菌的关系,探讨前列腺液病原菌检测的诊断价值及其临床意义. 方法对临床慢性前列腺炎患者的前列腺液进行细菌培养和药敏试验,同时检测沙眼衣原体和解脲脲原体. 结果 428例中有248例分离出细菌,阳性率为58%,细菌种类有11种,革兰阳性菌占78.63%,以表皮葡萄球菌为主;革兰阴性菌占21.37%,以大肠埃希菌为主;合并沙眼衣原体和(或)解脲脲原体感染73例,占29.43%;分离出的细菌对临床常用抗菌药物的耐药率较高,葡萄球菌属中耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)的产生率分别高达60%和48.5%,肠杆菌科细菌仅对亚胺培南和三代头孢的敏感性较高. 结论适时监测前列腺液病原菌及药敏试验对临床诊断和治疗慢性前列腺炎具有重要的意义.

Pathogenic Bacteria of Chronic Prostatitis:An Investigation of 428 Cases

OBJECTIVE To investigate the relationship between chronic prostatitis and the pathogenic bacteria, and study the diagnostic value and clinic significance of pathogenic diagonosis in prostatic fluid. METHODS Bacterial culture and antimicrobial agents sensitivity test were applied to prostatic fluid in 428 chronic prostatitis patients as well as Chlamydia trachomatis and Ureaplasma urealyticumwere detected. RESULTS Bacteria were found in 248 patients out of 428(58%). Eleven kinds of bacteria were found. Gram-positive bacteria were about 78.22% and Staphylococcus epidermidis was the most predominant. Gram-negative bacteria were about 21.78% and Escherichia coli was the most common. Seventy three patients were infected by C. trachomatis and/or U. urealyticum(29.43%). According to sensitivity test, the ratio of drug resistance of bacteria from prostatic fluid was high, the ratio of MRSA and MRCNS was 60% and 48.5%, respectively. Enterobacteriaceae were only sensitive to imipenem and third generation cephalosporins. CONCLUSIONS It is very important to apply bacterial culturing and sensitivity test to the diagnosis and therapy of chronic prostatitis.