急性脑梗死及其并发多脏器功能障碍综合征患者血清C反应蛋白水平的变化

目的　探讨急性脑梗死 (ACI)及其并发多脏器功能障碍综合征 (MODS)患者血清C反应蛋白(CRP)水平的变化及与MODS发生率的关系。方法　采用免疫透射比浊法测定 30名健康体检者 (正常对照组 )和 82例ACI患者血清CRP的含量 ,并对腔隙性脑梗死 (LCI)、急性单纯性脑梗死 (PACI)、ACI并发MODS患者的血清CRP水平进行比较。结果　ACI患者血清CRP水平与正常对照组比较显著升高 (P <0 0 1) ,PACI患者血清CRP水平显著高于LCI患者 ,ACI并发MODS患者又显著高于PACI患者 (均P <0 0 5 )。ACI患者MODS的发生率与血清CRP水平呈正相关 (r=0 94 ,P <0 0 5 )。结论　CRP与ACI及其并发MODS明显相关 ,血清CRP水平对判断ACI的预后是一个有效指标。

Change of serum C-reactive protein levels in patients with acute cerebral infarction and acute cerebral infarction with multiple organ dysfunction syndrome

Objective To investigate the change of serum C-reactive protein(CRP) levels in patients with acute cerebral infarction(ACI) and ACI with multiple organ dysfunction syndrome(MODS), and the relationship between serum CRP levels and incidence of MODS.Methods The serum CRP levels of 30 normal healthy people and 82 patients with ACI were detected by immune transmission turbidity method. The data from the patients with lacunar cerebral infarction(LCI), acute simple cerebral infarction(PACI) and ACI with MODS(ACI+MODS) were compared.Results The levels of serum CRP in patients with ACI significantly increased compared with the controls( P<0.01). The serum CRP levels of patients with PACI were significantly higher than those of patients with LCI, and they were also higher in patients of ACI+MODS compared with patients of PACI(all P<0.05). There was a positive correlation between the serum CRP level and the incidence of MODS in patients with ACI( r=0.94, P<0.05).Conclusion CRP is significantly correlated with ACI and the incidence of MODS. CRP is a useful marker to predict the prognosis of ACI.