| 十三种洋地黄属强心甙成分的反相高效液相分离 |
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| 引用本文： | 朱霁虹,李维庸.十三种洋地黄属强心甙成分的反相高效液相分离[J].药学学报,1987(7). |
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| 作者姓名： | 朱霁虹 李维庸 |
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| 作者单位： | 中国药品生物制品检定所 北京
(朱霁虹)，中国药品生物制品检定所 北京(李维庸) |
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| 摘 要： | 洋地黄属强心甙系由玄参科洋地黄属植物中提取出的混合物,是重要的治疗心脏病药物。由于其成分复杂,分离其所含的各强心甙成分十分困难。本文采用反相高效液相色谱法,在传统用于分离洋地黄强心甙成分的乙腈—水流动相系统中加入一定量甲醇作改进剂,并进行凹形梯度洗脱,大大改进了结构极为近似的强心甙的分离,13种洋地黄属强心甙化合物得到了满意的分离。
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| 关 键 词： | 强心甙 洋地黄毒甙 异羟基洋地黄毒甙 羟基洋地黄毒甙 毛花甙A B C 去乙酰毛花甙A B C |
SEPARATION OF 13 DIGITALIS GLYCOSIDES OF CARDENOLIDE GROUP BY REVERSED-PHASE HPLC |
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| ZHU Ji-Hong and LI Wei-Yong.SEPARATION OF 13 DIGITALIS GLYCOSIDES OF CARDENOLIDE GROUP BY REVERSED-PHASE HPLC[J].Acta Pharmaceutica Sinica,1987(7). |
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| Authors: | ZHU Ji-Hong and LI Wei-Yong |
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| Abstract: | Digitalis glycosides of cardenolide group are important constituents with closely similar structures isolated from Digitalis plants of Sreophulariaceae for the treatment of heart diseases. A reversed-phase HPLC has been developed to separate 13 digitalis glycosides successfully by using methanol as a modifier to acetonitrile-water in concave gradient elution from (A) CH_3CN-H_2O-MeOH (30:70:10) to (B) CH_3CN-H_2O-MeOH (52.5: 47.5: 12). The effects of methanol on the separation of the digitalis glycosides and the characteristics between retention time and structures are also hereby discussed. |
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| Keywords: | Cardiac glycoside Digitoxin Digoxin Gitoxin Lanatoside A B C Deslanoside A B C |
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