猪肝小肠联合移植模型的建立

目的 建立猪同种异体带胰头和十二指肠的肝小肠联合移植动物模型(LSBT)。方法 动物为杂交长白猪，供器官包括少部分胰头、十二指肠、肝脏以及近端空肠2～3m，整块移植物移植到去除肝脏和全部小肠的受者猪。结果 在没有应用免疫抑制剂的情况下，猪移植术后中位生存时间为92h，最长时间为196h，其中有75％的动物术后生存时间超过24h。结论 猪的带部分胰头和十二指肠的肝小肠联合移植模型的成功建立，为临床肝小肠联合移植的开展和研究打下了基础。

Establishment of porcine combined liver/small bowel transplantation model

ObjectiveTo set up the porcine combined liver/small bowel orthotopic allotransplantation model.MethodThe donors including liver, about 2 to 3?m proximal jejunum, duodenum and a sma ll part of pancreas head were transplanted to the hybridized long-white recipie nt pigs after the resection of their livers and the majority of small bowels.ResultWithout using immunosuppressive drugs, the median survival time of the animals w as 92?h with the longest survival time being 196?h, and there was about 75?% of the animals lived for more than 24?h after operation.ConclusionThe successful establishment of the combined liver/small bowel transplantation m odel will do great favor to our future clinical practice and further study of th e combined liver/small bowel transplantation.