ATP－MgCl_2对烫伤大鼠肠粘膜保护作用的实验观察

为研究ＡＴＰ－ＭｇＣｌ２对创伤应激动物肠粘膜的保护作用，采用３０％ＴＢＳＡⅢ度烫伤大鼠模型，观察了腹腔注射ＡＴＰ－ＭｇＣｌ２复合液对回肠粘膜丙二醛（ＭＤＡ）含量及回肠组织形态学改变的影响。结果显示：烫伤后６～２４小时，ＭＤＡ含量明显升高，并伴有形态学病理改变。经ＡＴＰ－ＭｇＣｌ２注射治疗的大鼠伤后２４小时内ＭＤＡ含量维持于正常对照水平，且回肠粘膜病理改变减轻。提示：ＡＴＰ－ＭｇＣｌ２能够保护烫伤大鼠肠粘膜，其作用机理可能与降低肠粘膜的脂质过氧化反应有关。

Protective effect of ATP-MgCl_2 on gut mucosa in burn rat

In order to study the protective effect of ATP-MgCl2 on gut mucosal barrier function in trauma-induced stressed animal, full thickness burn of 30% total body surface area(TBSA) was produced in rats, and ATP-MgCl2 was injected intraperitoneally right after scald-injury. Malondialdehyde (MDA) contents of ileum mucosa were determined and morphological aheration in the ileum was observed under light microscope. The results showed that ileum mucosal MDA content increased significantly, accompanied by obvious morphological change, after the injury, whereas MDA content was maintained at the normal control level and pathological alteration in ileum tissue was abated after the use of ATP-MgCl2. It suggests that ATP-MgCl2 possesses a protective effect on gut mucosal barrier function of scald-injured rat, and the mechanism involved may be related to the inhibition of lipid peroxidation in gut mucosa.