| 优选精制蛇毒酶乳膏剂制备工艺的实验分析 |
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| 引用本文： | 刘海军,孙晋民,贾秀坤,詹丽芬,郝丽英.优选精制蛇毒酶乳膏剂制备工艺的实验分析[J].山西医药杂志,2010,39(9):806-807. |
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| 作者姓名： | 刘海军 孙晋民 贾秀坤 詹丽芬 郝丽英 |
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| 作者单位： | [1]中国医科大学实验技术中心一部暨中药工程研究室,110001 [2]中国医科大学药学院,110001 |
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| 摘 要： | 目的优化精制蛇毒酶乳膏制备工艺。方法以乳膏剂的稳定性及外观性状为考察指标,采用正交实验设计法,以油相、水相、乳化温度和乳化时间为可变因素,选用L9(34)表进行实验。结果最优的基质组成工艺是:硬脂酸20.0 g、植物油10.0 g、液体石蜡8.0 g、丙三醇5.0 g、三乙醇胺1.0 g;混合乳化机搅拌60min;乳化温度85℃。结论按此法制备的乳膏剂符合中国药典软膏剂的规定。
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| 关 键 词： | 正交试验 软膏基质 工艺学 制药 |
Experimental analysis of optimization of snake venom enzyme cream preparation by orthogonal design method |
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| Abstract: | Objective To optimize snake venom enzyme cream preparation conditions.Methods The stability and appearance properties of the cream was the evaluating target,orthogonal design method was used.The oil phase and water phase,emulsification temperature and emulsification time were selected as variable factors and table L9(34)was used to do experiment.Results The optimum matrix composition and technology were: stearic Acid 20.0 g,vegetable oil 10.0 g,liquid paraffin 8.0 g,glycerine 5.0 g,TEA 1.0 g.It was mixed for 60 minutes with cutting emulsifier.emulsification temperatur 85 ℃.Conclusion The cream prepared by this kind of composition and technology accord with the stipulation of Chinese Pharmacopoeia. |
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| Keywords: | Orthogonal test Ointmen bases Technology pharmaceutical |
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